Alcohols and polyols
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- (50)
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- (1)
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- (1)
- (26)
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- (1)
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- (1)
- (462)
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- (1)
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- (114)
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- (1)
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- (10)
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- (15)
- (1)
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- (6)
- (2)
- (2)
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- (2)
- (4)
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- (1)
- (28)
- (29)
- (7)
- (3)
- (5)
- (1)
- (36)
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- (4)
- (2)
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- (17)
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- (2)
- (5)
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- (33)
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- (2)
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- (8)
- (2)
- (2)
- (8)
- (7)
- (7)
- (2)
- (1)
- (26)
- (1)
- (1)
- (1)
- (2)
- (1)
- (3)
- (4)
- (3)
- (1)
- (15)
- (12)
- (1)
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- (2)
- (7)
- (12)
- (1)
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- (24)
- (1)
- (8)
- (4)
- (1)
- (2)
- (1)
- (17)
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- (2)
- (1)
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- (24)
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- (1)
- (1)
- (1)
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- (2)
- (4)
- (11)
- (2)
- (7)
- (4)
- (1)
- (1)
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- (1)
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- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.63% | C17H19ClN4O | 50 MG
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Alosetron Hydrochloride is a potent and highly selective antagonist of the serotonin 5-HT3 receptor. It is researched for its application in irritable bowel syndrome (IBS). The compound effectively blocks the rapid 5HT3-mediated depolarization in guinea-pig myenteric and submucosal neurons, with an IC50 of approximately 55 nM. It also demonstrates an ability to lessen the visceral nociceptive effects of rectal distension in conscious or anesthetized dogs, and exhibits anti-inflammatory properties.
- Highly selective antagonist of the serotonin 5-HT3 receptor.
- Under investigation for irritable bowel syndrome.
- Blocks 5HT3-mediated depolarization.
- Attenuates visceral nociceptive effects.
- Exhibits anti-inflammatory effects.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 50 MG
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EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor, reducing H3K79me2 and H3K79me1 levels and down-regulating HOXA9 and MEIS1 expression. This compound selectively inhibits the proliferation of MLL rearrangement cells, promoting their differentiation and apoptosis, making it useful for leukemia research.
- Target: histone methyltransferase; apoptosis
- Pathway: epigenetics; apoptosis
- Potent and selective DOT1L inhibitor (IC50 of 0.4 nM)
- Reduces H3K79me2 and H3K79me1 levels, down-regulating HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cells, promoting differentiation and apoptosis
- Well tolerated in vivo with no overt toxicity observed
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 25 MG
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Dopexamine hydrochloride is a β2 adrenergic receptor agonist and a dopamine analogue. It exhibits agonist activity at β2 and dopaminergic receptors, attenuating systemic inflammatory response, reducing tissue leukocyte infiltration, and protecting against organ injury. It can reduce the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without significantly altering systemic hemodynamics.
- Agonist activity at β2 and dopaminergic receptors
- Attenuates systemic inflammatory response
- Reduces tissue leukocyte infiltration
- Protects against organ injury
- Stimulates β-adrenergic and dopamine 1 and 2 receptors
- Confers vasodilatory effects
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Aplaviroc hydrochloride | 461023-63-2 | 99.9% | 614.17 | 100 MG
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Aplaviroc hydrochloride is a potent CCR5 antagonist, effective against wild-type R5 HIV-1 strains with IC50 values of 0.1 to 0.4 nM. It also suppresses the infectivity and replication of HIV-1MDR variants at low concentrations. This compound binds to CCR5 with high affinity and has been shown to suppress R5 HIV-1 viremia in animal models. Aplaviroc hydrochloride has been involved in multiple clinical trials for HIV infection.
- Potent CCR5 antagonist
- Effective against wild-type R5 HIV-1 strains
- Suppresses HIV-1MDR variants
- Binds to CCR5 with high affinity
- Suppresses R5 HIV-1 viremia in animal models
- Investigated in clinical trials for HIV infection
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Medchemexpress LLC Endoxifen (hydrochloride) | 1197194-41-4 | 98.0% | 409.95 | 100 MG
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Endoxifen hydrochloride is a key active metabolite of Tamoxifen with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. It has potential for breast cancer study.
- More potent ER antagonist than tamoxifen.
- Induces ER-alpha degradation and inhibits ER transcriptional activity.
- Targets estrogen receptor α for degradation in breast cancer cells, inhibiting proliferation.
- Exhibits strong growth inhibitory and cytotoxic effects on breast cancer cell lines at 10 μM.
- Rapidly absorbed and systemically available; leads to higher exposure levels than tamoxifen.
- Safe and effective in inhibiting human mammary tumor xenografts in female mice orally.
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Medchemexpress LLC Gyki 53655 (hydrochloride) | 143692-48-2 | 98.4% | 388.85 g·mol⁻¹ | C19H21ClN4O3 | 100 MG
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GYKI 53655 hydrochloride is a research-grade small molecule that acts as a non-competitive antagonist of AMPA and kainate receptors. It is supplied as a light yellow to yellow solid with reported purity of ~98.4% and molecular formula C19H21ClN4O3. Intended for in vitro research use only.
- Non-competitive AMPA and kainate receptor antagonist.
- High purity (~98.4%) for consistent experimental results.
- Light yellow to yellow solid, soluble in DMSO and water with recommended handling precautions.
- Recommended storage: solid at 4°C; prepared solutions at -80°C (up to 6 months) or -20°C (short term).
- Available in multiple solid sizes, including 100 mg, for lab-scale studies.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428816 YOHIMBINE HYDROCHLO 10G
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eMolecules EMOLECULES INC
5000567104 PICOLINIMIDAMIDE HYDROCHLO 10G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000693300 CYCLIZINE HYDROCHLO 250MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000743504 FILANESIB HYDROCHLO 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000744097 TOPOTECAN HYDROCHLO 50MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000745784 PRASUGREL HYDROCHLO 25MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000745898 ENPATORAN HYDROCHLO 10MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000746519 SB-505124 HYDROCHLO 10MG
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Medchemexpress LLC Trazodone hydrochloride | 25332-39-2 | 99.6% | 500 MG
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Trazodone hydrochloride is a triazolopyridine derivative classified as a serotonin receptor antagonist and reuptake inhibitor (SARI). It demonstrates anti-depressant and anti-insomnious activity. The compound exerts antagonistic properties against α1- and α2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects.
- Serotonin receptor antagonist and reuptake inhibitor (SARI)
- Exhibits anti-depressant and anti-insomnious activities
- Antagonizes α1- and α2-adrenergic receptors and histamine H1 receptors
- Minimal anticholinergic effects
- Binds to 5-HT1A receptor
- Reduces expression of neuroinflammatory markers
- Increases mRNA expression of BDNF and CREB
- Demonstrates neuroprotective effects
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