An a4ß2 subunit-containing nAChR agonist selectively induces rubidium ion efflux in M10 cells expressing a4ß2 subunit-containing nAChRs (EC50 0.73 UM for the chicken channels) over M10 cells expressing a3ß4- or a1ß1?d subunit-containing receptors (EC50s >1000 nM for both for the chicken channels) and a panel of 34 receptors ion channels and kinases at 10 UM induces contractions in isolated guinea pig ileum (EC30 15 UM) prevents scopolamine-induced memory deficits in the passive avoidance test in mice at 0.6 Umol/kg decreases the number of errors in the radial arm maze in a rat model of ibotenic acid-induced memory impairment at 0.3 0.6 or 1.2 Umol/kg