Organic disulfides
Medchemexpress LLC Diphenyl disulfide | 882-33-7 | MFCD00003065 | 100.0% | 218.35 g/mol | C12H10S2 | 1g
Diphenyl disulfide is an endogenous metabolite Diphenyl disulfide is a pharmaceutical intermediate Diphenyl disulfide can be coupled with aryl iodide to synthesize asymmetric aryl sulfide[1][2]
TARGETMOL CHEMICALS INC NX-2127 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells. Purity 98.11%
eMolecules Ambeed / 2-(4-Nitrobenzamido)acetic acid / 1g / 586036432 / A703345 / / 2645-07-0 / MFCD00007349 / 224.172 / C9H8N2O5
Ambeed / 2-(4-Nitrobenzamido)acetic acid / 1g / 586036432 / A703345 / / 2645-07-0 / MFCD00007349 / 224.172 / C9H8N2O5
Medchemexpress LLC PROTAC degrader targeting Bruton's tyrosine kinase (BTK) | 2416131-46-7 | 99.7% | 719.83 | C39H45N9O5 | 10 MG
NX-2127 is an orally bioavailable PROTAC degrader that targets Bruton's tyrosine kinase (BTK). It induces proteasomal degradation of BTK, shows activity against BTK C481S resistance mutants, degrades IKZF1 and IKZF3 transcription factors, and has demonstrated cellular and in vivo preclinical activity while promoting T cell activation and IL-2 production.
- Orally bioavailable PROTAC degrader of BTK.
- Induces proteasomal degradation of BTK and reduces BTK signaling.
- Active against BTK C481S resistance mutants in cellular models.
- Degrades IKZF1 and IKZF3, providing immunomodulatory effects.
- Stimulates T cell activation and increases IL-2 production in primary human T cells.
- Demonstrated efficacy in preclinical in vivo models.
Medchemexpress LLC (R)-Zelebrudomide | 3024312-52-2 | C39H45N9O5 | 100 MG
(R)-Zelebrudomide ((R)-NX-2127) is an isomer of the BTK PROTAC degrader Zelebrudomide. It is composed of a BTK ligand, (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline, and Thalidomide 5-fluoride. This product is intended for research use only.
- Isomer of the BTK PROTAC degrader Zelebrudomide
- Composed of a BTK ligand, (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline, and Thalidomide 5-fluoride
- For research use only
- High purity (98.93%)
Medchemexpress LLC (R)-NX-2127 | 3024312-52-2 | 98.9% | 719.83 | C39H45N9O5 | 10 MG
(R)-NX-2127 is the R-isomer of a Bruton's tyrosine kinase (BTK) PROTAC degrader supplied as a high-purity solid for preclinical research. The compound is intended for use in studies of BTK degradation and related cellular pharmacology; consult the supplier product page and SDS for handling and storage details.
- R-isomer of a BTK PROTAC degrader
- High reported purity (98.93%)
- Molecular weight 719.83
- Chemical formula C39H45N9O5
- Solid, light yellow to yellow appearance
- Recommended storage: 4°C protected from light; in solvent -80°C (6 months) or -20°C (1 month)
- Intended for preclinical BTK degradation and cellular assays
Medchemexpress LLC Hydroxyethyl disulfide | 1892-29-1 | MFCD00002906 | 98.8% | 154.25 g/mol | C4H10O2S2 | 10 G
Hydroxyethyl disulfide is a small-molecule laboratory reagent used in biochemical research. It is reported to interact with thymidylate synthase pathways and is provided with supporting documentation such as a certificate of analysis and safety data sheet. The compound is commonly used as a reagent or intermediate in chemical and biochemical studies.
- Purity 98.8% (reported)
- Cas number 1892-29-1
- Molecular formula C4H10O2S2
- Molecular weight 154.25 g/mol
- Available as a 10 G package