Sulfonyls
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Medchemexpress LLC Sulfathiazole | 72-14-0 | 99.7% | 5 G
Sulfathiazole is an orally active compound identified as an endocrine disruptor. It specifically targets the steroidogenic pathway by enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and increasing the mRNA expression of CYP17, CYP19, and 3β-HSD. This leads to an increased production of 17-estradiol (E2) and has been observed to cause endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish.
- Orally active.
- Targets the steroidogenic pathway.
- Enhances CYP19 activity in human adrenal cancer cells (H295R).
- Upregulates mRNA expression of CYP17, CYP19, and 3β-HSD.
- Increases 17-estradiol (E2) production.
- Exhibits endocrine disrupting effects on aquatic organisms (e.g., Japanese medaka fish).
- Can inhibit the corrosion of copper in 0.1 M NaCl solution, with efficiency exceeding 80% at increased concentrations.
