Sulfoxides
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.1% | 315.80 | 25 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. This compound induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes, and inhibits tumor growth in CDX mice models. It is suitable for cancer research, including leukemia.
- Potent and selective CDK9 inhibitor (IC50 = 5.9 nM)
- Inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain
- Induces apoptosis in tumor cells
- Suppresses expression of CDK9-regulated genes (e.g., MYC and Mcl1)
- Inhibits tumor growth in CDX mice models
- High selectivity over CDK1 and CDK2
- Does not inhibit hERG channel activity at concentrations up to 30 μM
- Demonstrates a good safety profile in animal models
TARGETMOL CHEMICALS INC METHOTREXATE METABOLITE 50MG
Also available in 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. purity: 99%
Medchemexpress LLC Sirtuin modulator 1 | 2070015-26-6 | MFCD29924722 | 99.9% | 10 MG
Sirtuin modulator 1 is a small-molecule modulator of SIRT1 (a homolog of SIRT3) reported with an EC1.5 of <1 μM and described in patent WO 2010071853 A1 (Compound No. 4). Supplied as a high-purity solid for research use, it is intended for biochemical and cellular studies of sirtuin activity.
- High reported purity for assay-ready use.
- Molecular formula C31H32ClN5O2S2, molecular weight 606.20 g/mol.
- CAS number 2070015-26-6 for unambiguous identification.
- Reported EC1.5 potency of <1 μM against SIRT1.
- Available in milligram-scale quantities suitable for research.
Medchemexpress LLC GPR120 modulator 1 | 1050506-75-6 | 98.06% | C19H16ClNO4S | 50 MG
GPR120 modulator 1 is a G protein-coupled receptor 120 (GPR120) modulator, extracted from patent US8394841B2, compound example F1. It is intended for research use only and can be used for the study of diseases associated with abnormal or deregulated GPR120, such as diabetes.
- G protein-coupled receptor 120 (GPR120) modulator
- Extracted from patent US8394841B2, compound example F1
- Useful for research of diseases associated with abnormal or deregulated GPR120, such as diabetes
- For research use only
Medchemexpress LLC Sirtuin modulator 3 50mg | 50mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Apexbio Technology LLC INCB024360 analogue 914471-09-3 10mM (in 1mL DMSO)
INCB024360 analogue (CAS 914471-09-3) is a selective inhibitor of indoleamine 2 3-dioxygenase 1 (IDO1) an enzyme responsible for initiating tryptophan catabolism along the kynurenine pathway IDO1-mediated depletion of tryptophan in the tumor microenvironment can suppress T-cell proliferation and promote immune tolerance facilitating cancer immune evasion INCB024360 analogue inhibits human IDO1 with an IC50 of 67 nM and demonstrates minimal activity against the related enzyme TDO In vivo studies in mouse melanoma models reveal dose-dependent anti-tumor activity and significant reductions in kynurenine levels supporting its utility as a research tool to investigate IDO1-targeted immunotherapy strategies
Medchemexpress LLC IL-17 modulator 3 | 2467731-88-8 | 99.51% | 579.73 | 1 ML
IL-17 modulator 3 is an IL-17 modulator that can be used for the research of inflammation, cancer, and autoimmune diseases. This product is for research use only and not sold to patients.
- Used for research of inflammation
- Used for research of cancer
- Used for research of autoimmune diseases
Medchemexpress LLC Fast garnet GBC sulfate salt | 101-89-3 | MFCD00011883 | 90.0% | 334.35 g·mol⁻¹ | C14H14N4O4S | 100 MG
Fast garnet GBC sulfate salt, 90% is a chromogenic substrate for alkaline phosphatase used in histology and biochemical assays. It yields a red-violet azo precipitate at enzyme activity sites and is supplied in small pack sizes for research use, including 50 mg, 100 mg, and 250 mg. CAS 101-89-3; molecular weight 334.35 g·mol⁻¹.
- Chromogenic substrate for alkaline phosphatase staining and detection.
- Approximately 90% purity suitable for research applications.
- Produces a red-violet azo precipitate for clear visualization.
- Available in small pack sizes for laboratory use.
- Supplied as the sulfate salt with CAS number 101-89-3.
Medchemexpress LLC Glp-1r modulator l7-028 | 2648317-95-5 | 99.5% | C24H28N2O3 | 1 ML
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R through a transmembrane site, with an EC50 of 11.01 ± 2.73 μM.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R via a transmembrane site
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 50 MG
GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).
- Enhances GLP-1 binding to GLP-1R.
- Acts via a transmembrane site.
- High purity of 98.7% confirmed by LCMS.
- Recommended storage conditions for powder: -20°C for 3 years, 4°C for 2 years.
- Recommended storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 1 ML
Mutant p53 modulator-1 is a compound that acts as a modulator of mutant p53. It has been shown to reduce the progression of cancers that possess a p53 mutation. This compound is identified as 231B in patent WO2021231474A1.
- Molecular weight: 576.59
- Appearance: Solid
- Color: Light yellow to brown
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder at -20°C for 3 years, 4°C for 2 years. In solvent at -80°C for 6 months, -20°C for 1 month
- Solubility (in vitro): 100 mg/mL (173.43 mM) in DMSO (requires sonication; hygroscopic DMSO significantly impacts solubility, use newly opened DMSO)
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | 99.88% | 50 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. It can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM)
- Selectively reduces Aβ42 production
- Used for researching Alzheimer's disease
Medchemexpress LLC Triclabendazole sulfoxide | 100648-13-3 | MFCD09038493 | 98.8% | C14H9Cl3N2O2S | 10MG
Triclabendazole sulfoxide is the primary plasma metabolite of triclabendazole; it shows antiparasitic activity and has been reported to inhibit the ABCG2/BCRP transporter. Supplied for research use, it is typically used in pharmacology and transporter inhibition studies.
- Main plasma metabolite of triclabendazole.
- Exhibits antiparasitic activity.
- Inhibits ABCG2/BCRP transporter.
- Provided as a research-use reagent, not for human use.
- Stable under recommended cold storage conditions for extended periods.