Thioacetals

ALADDIN SCIENTIFIC CORPORATION Thioacetamide, 25g

Thioacetamide is a thiocarbonyl compound It undergoes deuterium exchange reaction with D2O to afford N-dideuterated thioacetamide Infrared spectral investigations of thioacetamide and its deuterated derivative (N-dideuterated thioacetamide) have been reported Usually used as Hepatotoxin and carcinogenand also used as an additive in enantioselective reduction of -keto esters with immobilized baker s yeast Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide which is a highly reactive metabolite and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis Thioacetamide can induce chronic liver fibrosis encephalopathy and other events model