Anthracyclines
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Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | MFCD00077757 | C27H30ClNO11 | 2 G
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic and a potent anti-cancer chemotherapy agent. It functions as a human DNA topoisomerase I and II inhibitor, reducing basal phosphorylation of AMPK and inducing apoptosis and autophagy. This orange-red crystalline solid is isolated from cultures of Streptomyces peucetius var. caesius.
- Potent human DNA topoisomerase I and II inhibitor
- Reduces basal phosphorylation of AMPK
- Induces apoptosis and autophagy
- Functions as a DNA intercalator
- Acts as a fluorescent dye
- Exhibits antitumor and antibiotic activity
- Inhibits reverse transcriptase and RNA polymerase
