Anthracyclines
Apexbio Technology LLC BIIE 0246 246146-55-4 1mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior
Apexbio Technology LLC BIIE 0246 246146-55-4 10mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior