Cinnamic acids and derivatives
AdipoGen Curcumin high purity
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.4. Synthetic. Originally isolated from turmeric Curcuma longa. Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4 and inflammation NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX. Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Sonic hedgehog Shh signaling pathway modulator. Downregulates Shh and Gli1. Antioxidant. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 COX-2, lipooxygenase LOX, and inducible nitric oxide synthase iNOS NOSII. Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Potent immunomodulator.
