Linear 1 3-diarylpropanoids
Medchemexpress LLC Naringin Dihydrochalcone | 18916-17-1 | 99.2% | 582.55 | 5 G
Naringin Dihydrochalcone is an artificial sweetener synthesized from naringin, a flavanone glycoside naturally found in citrus fruits like tomatoes and grapefruits. It demonstrates various biological properties, including antioxidant, anti-inflammatory, and antiapoptotic effects, and is known to suppress the NF-κB signaling pathway.
- Artificial sweetener.
- Derived from naringin, a flavanone glycoside.
- Exhibits antioxidant, anti-inflammatory, and antiapoptotic activities.
- Suppresses NF-κB signaling pathway.
- Inhibits high glucose-induced proliferation and oxidative stress in HBZY-1 cells.
- Induces autophagic cell death in AGS cancer cells.
- Protects PC12 cells from neurotoxicity and enhances antioxidant defense.
- Alleviates renal injury, collagen deposition, and fibrosis in diabetic rats.
- Improves learning, memory, and insulin signaling in high-fat diet-induced obese mice.
Apexbio Technology LLC NARINGIN-DIHYDROCHALCONE-200MG
Naringin Dihydrochalcone (CAS No 18916-17-1) is a flavonoid derivative commonly researched in the fields of pharmacology and nutrition It originates from citrus fruits particularly grapefruit and acts as a potent sweetening agent Its mechanism involves modulation of taste receptors and potential effects on cellular pathways related to oxidative stress In vitro it exhibits activity in the nanomolar to low micromolar range It is utilized in various experimental settings including cell models for antioxidant and anti-inflammatory studies as well as animal studies evaluating metabolic effects Drug screening often explores its potential in improving oral bioavailability and reducing bitterness in formulations Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC Phloretin 60-82-2 10mM (in 1mL DMSO)
Phloretin (CAS 60-82-2) is a naturally occurring dihydrochalcone phenolic compound derived primarily from apple leaves and Manchurian apricot It functions as an inhibitor of sodium-glucose linked transporters (SGLT1 and SGLT2) proteins involved in glucose uptake and reabsorption in intestinal and renal tissues Phloretin inhibits glucose uptake via these transporters exhibiting an IC50 of approximately 49 12 M In cell-based studies it enhances lipolysis increases AMP-activated protein kinase (AMPK) phosphorylation and suppresses adipogenic transcription factors and MAPK signaling Animal research demonstrates that oral administration of Phloretin reduces blood glucose and improves lipid profiles in diabetic mouse models highlighting its utility in metabolic research
Chem-Impex International, Inc. Neohesperidin dihydrochalcone hydrate | MFCD03840557 | 1G
Neohesperidin dihydrochalcone hydrate, MFCD03840557, 1G
Aobchem 1-(4-Ethylphenyl)-1-propanone | ≥97% | CAS 27465-51-6 | C11H14O | 100g
1-(4-Ethylphenyl)-1-propanone | ≥97% | CAS 27465-51-6 | C11H14O | 100g
Aobchem 1-Propanone 1-(5-chloro-2-methoxyphenyl)-2-methyl- | 95% | CAS 848997-63-7 | C11H13ClO2 | 1g
1-Propanone 1-(5-chloro-2-methoxyphenyl)-2-methyl- | 95% | CAS 848997-63-7 | C11H13ClO2 | 1g
TARGETMOL CHEMICALS INC AKT-I-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. AKT-I-1 is a selective and reversible inhibitor of Akt1. purity: 98%
TARGETMOL CHEMICALS INC Naringenin 1G
Also available in 1 mL, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA. Purity 98.81%
Medchemexpress LLC (±)-Naringenin (Standard) | 67604-48-2 | 98.8% | 272.25 | 100 MG
(±)-Naringenin (Standard) is the analytical standard of (±)-Naringenin, intended for research and analytical applications. It is a naturally-occurring flavonoid that displays a vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- Analytical standard grade
- Naturally-occurring flavonoid
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Appearance: solid, white to light yellow
- Structure classification: flavonoids, phenols
- Initial source: plants other families
- Displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
Medchemexpress LLC AKT-IN-23 | 1226801-23-5 | 517.52 | 25 MG
AKT-IN-23 is an AKT inhibitor primarily used in cancer research. This compound is known for its specific targeting capabilities.
- Acts as an AKT inhibitor
- Suitable for cancer research applications
- Targets Akt
- Involves the PI3K/Akt/mTOR pathway
![Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387556-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML
AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. It potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473. In vivo, it causes significant tumor growth inhibition in breast adenocarcinoma xenograft models.
- Allosteric AKT inhibitor.
- Potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM respectively.
- Inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway.
- Potently inhibits the phosphorylation of PRAS40.
- In vivo, potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473).
- Causes significant tumor growth inhibition in BT474c breast adenocarcinoma xenograft models when dosed at 200 mg/kg daily.
TARGETMOL CHEMICALS INC 4 4 -Dimethoxychalcone 50MG
Also available in 1 mL, 25 mg, 100 mg and bulk. Please contact Fisher for quotes.4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product. Purity 99.35%
Medchemexpress LLC (±)-Naringenin (Standard) | 67604-48-2 | 98.8% | 272.25 | 25 MG
(±)-Naringenin (Standard) is the analytical standard of (±)-Naringenin. It is a naturally-occurring flavonoid intended for research and analytical applications. It displays a vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- Used as a reference standard in qualitative, quantitative, and methodological research experiments.
- Commonly applied in techniques such as HPLC, GC, and MS.
- Appearance is a solid, white to light yellow.
- Chemical formula is C₁₅H₁₂O₅.
- Classified under flavonoids and phenols.
- Initial source is from other plant families.
![eMolecules 480-41-1 | (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3966901.jpg-250.jpg)
eMolecules 480-41-1 | (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953
(S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | 480-41-1 | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953