Linear 1 3-diarylpropanoids
Medchemexpress LLC AKT-IN-6 | 1430056-54-4 | 99.1% | 389.43 | 1 ML
AKT-IN-6 is a potent Akt inhibitor that targets Akt1, Akt2, and Akt3 with IC50s below 500 nM. Akt is a central node in cell signaling, and its aberrant activation is linked to various complex diseases, including type-2 diabetes and cancer.
- Potent Akt inhibitor
- Targets Akt1, Akt2, and Akt3
- Suitable for research applications
Selleck Chemical LLC Chalcone
Chalcone (benzylideneacetophenone phenyl styryl ketone benzalacetophenone -phenylacrylophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds which are known collectively as chalcones with antibacterial antifungal antitumor and anti-inflammatory properties
Medchemexpress LLC Xanthohumol | 6754-58-1 | 99.9% | 354.40 | 5 MG
Xanthohumol is a principal flavonoid isolated from hops. It inhibits diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2, and demonstrates anti-cancer, anti-angiogenic, and antiviral activities against viruses like bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2, and cytomegalovirus (CMV).
- Derived from hops
- Inhibits diacylglycerol acetyltransferase (DGAT)
- Inhibits COX-1 and COX-2
- Exhibits anti-cancer activity
- Exhibits anti-angiogenic activity
- Possesses antiviral activity
- Classified as a flavonoid, chalcone, phenol, and polyphenol
Selleck Chemical LLC Xanthohumol
Xanthohumol a prenylated chalcone from hop inhibits COX-1 and COX-2 activity and shows chemopreventive effects Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 M Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses Xanthohumol induces growth inhibition and apoptosis in cancer cells Phase 1
Medchemexpress LLC Xanthohumol | 6754-58-1 | MFCD00210576 | 99.3% | 354.40 g/mol | C21H22O5 | 10 MG
Xanthohumol (Standard) is an analytical reference standard of xanthohumol, a prenylated chalconoid flavonoid isolated from hops, supplied for research and analytical use in qualitative and quantitative assays and method development for HPLC, GC, and MS.
- Purity 99.30%.
- Molecular formula C21H22O5.
- Molecular weight 354.40 g/mol.
- Supplied as a solid, typically 10 mg.
- Intended for use as an analytical standard for HPLC, GC, and MS assays.
- Certificate of analysis provided; follow storage conditions in the CoA.
Medchemexpress LLC Xanthohumol C | 189299-05-6 | 99.2% | 352.38 | C21H20O5 | 10 MG
Xanthohumol C is a prenylchalcone natural product isolated from the hops plant Humulus lupulus. It is used in research and has reported cytotoxic and antiproliferative activity in human cancer cell lines.
- Chemical formula C21H20O5.
- Molecular weight 352.38.
- Purity 99.2%.
- Reported cytotoxicity against HeLa cells (IC50 12.5 μM).
- Antiproliferative activity against MCF7 cells (IC50 15.7 μM for 2 days, 6.87 μM for 4 days).
- Supplied as a 10 MG research quantity.
Medchemexpress LLC Xanthohumol C | 189299-05-6 | 352.38 | 5 MG
Xanthohumol C is a prenylchalcone that can be isolated from the hops of Humulus lupulus. It is categorized as a natural compound with a molecular weight of 352.38 and a chemical formula of C21H20O5. This compound appears as a light yellow to yellow solid and is intended for research use only, not for sale to patients.
- It is a prenylchalcone, a type of natural compound.
- It can be isolated from the hops of Humulus lupulus.
- It exhibits cytotoxicity against human HeLa cells with an IC50 of 12.5 μM.
- It shows antiproliferative activity against human MCF7 cells with IC50 values of 15.7 μM (2 days) and 6.87 μM (4 days).
Selleck Chemical LLC Phlorizin S2343-1g
Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis) apple cherry and other fruit trees Phlorizin is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2 respectively Phlorizin is also a Na /K -ATPase inhibitor
Medchemexpress LLC Phlorizin | 60-81-1 | MFCD00006652 | ≥98% | 436.43 | 1 G
Phlorizin is a biochemical reagent that acts as a non-selective SGLT inhibitor (hSGLT1 Ki: 300 nM, hSGLT2 Ki: 39 nM) and a Na+/K+-ATPase inhibitor. It is suitable for use as a biological material or organic compound in life science research.
- Non-selective SGLT inhibitor
- Na+/K+-ATPase inhibitor
- Classification: Flavonoids, Phenols, Polyphenols, Dihydrochalcones
- Source: Malus pumila Mill. (Rosaceae), Plants
- Targets: SGLT, Na+/K+ ATPase
- Research areas: Metabolic disease
Selleck Chemical LLC Isoliquiritigenin 50mg 961-29-5
Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
MP Biomedicals, Inc 2,4,4'-Trihydroxybenzalacetophenone, MP Biomedicals
CAS: 83616-07-3 Molecular Formula: C15H12O4 Molecular Weight (g/mol): 256.26 MDL Number: MFCD00049007 InChI Key: VDYSHUXENHRSOO-UHFFFAOYSA-N Synonym: 2,4,4'-trihydroxychalcone,3-2,4-dihydroxyphenyl-1-4-hydroxyphenyl prop-2-en-1-one,2,4,4'-trihydroxy benzalacetophenone,2-propen-1-one, 3-2,4-dihydroxyphenyl-1-4-hydroxyphenyl PubChem CID: 5057077 IUPAC Name: 3-(2,4-dihydroxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one SMILES: OC1=CC=C(C=C1)C(=O)C=CC1=C(O)C=C(O)C=C1
2',4,4'-Trihydroxychalcone, 97%, Thermo Scientific™
CAS: 961-29-5 Molecular Formula: C15H12O4 Molecular Weight (g/mol): 256.257 MDL Number: MFCD00075907 InChI Key: DXDRHHKMWQZJHT-FPYGCLRLSA-N Synonym: isoliquiritigenin,2',4,4'-trihydroxychalcone,4,2',4'-trihydroxychalcone,6'-deoxychalcone,e-1-2,4-dihydroxyphenyl-3-4-hydroxyphenyl prop-2-en-1-one,2',4',4-trihydroxychalcone,isoliquirtigenin,unii-b9cti9gb8f,ccris 7676,chalcone, 2',4,4'-trihydroxy PubChem CID: 638278 ChEBI: CHEBI:310312 IUPAC Name: (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one SMILES: C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
4,4'-Difluorochalcone 97.0+%, TCI America™
CAS: 2805-56-3 Molecular Formula: C15H10F2O Molecular Weight (g/mol): 244.24 MDL Number: MFCD00219906 InChI Key: AZBVDMNDUOURGI-XCVCLJGOSA-N Synonym: 4,4'-difluorochalcone,e-1,3-bis 4-fluorophenyl prop-2-en-1-one,2e-1,3-bis 4-fluorophenyl prop-2-en-1-one,1,3-bis 4-fluorophenyl prop-2-en-1-one,trans-4,4'-difluorochalcone,2-propen-1-one,1,3-bis 4-fluorophenyl,4,4'-difluoro chalcone,4,4/'-difluorochalcone,e-4,4'-difluorochalcone,azbvdmnduourgi-xcvcljgosa PubChem CID: 5286094 IUPAC Name: (2E)-1,3-bis(4-fluorophenyl)prop-2-en-1-one SMILES: FC1=CC=C(\C=C\C(=O)C2=CC=C(F)C=C2)C=C1