Linear 1 3-diarylpropanoids
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Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies
