Linear 1 3-diarylpropanoids
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Medchemexpress LLC Dibenzoylmethane | 120-46-7 | MFCD00003085 | 98.0% | 224.26 | 25 G
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. It is an analog of curcumin and results in dissociation from Keap1 and nuclear translocation of Nrf2. It is for research use only and not sold to patients.
- Activates Nrf2.
- Helps prevent various cancers and oxidative damage.
- Functions as an analog of curcumin.
- Leads to dissociation of Keap1 and nuclear translocation of Nrf2.
- Available in solid form, off-white to light yellow in color.
- Suitable for in vitro and in vivo studies.
- Stable for 3 years when stored as a solid at room temperature.
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Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 1 G
Dibenzoylmethane is a minor ingredient found in licorice that functions as a Keap1-Nrf2 activator. It is known to prevent various cancers and oxidative damage. As an analog of curcumin, it facilitates dissociation from Keap1, leading to the nuclear translocation of Nrf2.
- Activates Nrf2
- Prevents various cancers and oxidative damage
- Increases mRNA level of HO-1 in HepG2 cells
- Induces HO-1 and Nrf2 protein expression
- Increases phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells
- Reduces area and severity of necrosis and leukocyte infiltration
- Protects against CCl4-induced liver damage