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Tetracyclines

Organic compounds comprising a linearly fused tetracyclic backbone to which a variety of functional groups can be attached; they have an octahydrotetracene-2-carboxamide skeleton, and are known as derivatives of polycyclic naphthacene carboxamide.

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Medchemexpress LLC Sancycline (Bonomycin; 6-demethyl-6-deoxytetracycline) | 808-26-4 | 98.0% | 414.41 | 100 MG
SDP

Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome, similar to tetracycline. It is a semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin. Sancycline has been shown to decrease 2 chloroethyl ethyl sulfide (CEES) and nitrogen mustard (NM) induced corneal injuries and inhibit Matrix metalloproteinase (MMP)-9 expression in the basement membrane zone (BMZ).

  • Reversibly binds to 30 S ribosomal subunit
  • Inhibits protein translation
  • Decreases CEES and NM induced corneal injuries
  • Inhibits MMP-9 expression

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