Actinide Salts
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Cayman Chemical AlendronatesodIum hydrate 1g
An FPP synthase inhibitor (IC50 = 50 nM for the recombinant human enzyme); inhibits bone resorption in a pit formation assay using isolated rat osteoclasts (IC50 = 2 nM); reduces angiotensin II-induced collagen I synthesis in isolated rat cardiac fibroblasts at 3 and 10 µM; prevents femoral bone mineral density loss in ovariectomized rats at 5 mg/kg
