Carboxylic acids and derivatives
Medchemexpress LLC BRL-44408 maleate | 681806-46-2 | 99.0% | 10 MG
BRL-44408 maleate is a selective, blood-brain barrier-permeable α2A-adrenergic receptor antagonist with a Kᵢ value of 8.56 nM against human targets. It exhibits antidepressant and analgesic effects, and attenuates sepsis-induced acute lung injury by regulating neurotransmitter release or inhibiting signaling pathways. It can be used in studies related to acute respiratory distress syndrome, depression, and visceral pain.
- Selective α2A-adrenergic receptor antagonist
- Blood-brain barrier permeable
- Exhibits antidepressant and analgesic effects
- Attenuates sepsis-induced acute lung injury
- Regulates neurotransmitter release and inhibits signaling pathways
- Used in studies for acute respiratory distress syndrome, depression, and visceral pain
Cayman Chemical FluoresceIn dIacetate 5g
A cell-permeable fluorogenic cell viability probe; cleaved by intracellular esterases to produce fluorescein which displays excitation/emission maxima of 490/520 nm, respectively
Pfaltz & Bauer a-Ketobutyric Acid Sodium Sal 5G | 2013-26-5
a-Ketobutyric Acid Sodium Sal 5G | 2013-26-5
Medchemexpress LLC Indacaterol maleate | 753498-25-8 | MFCD20526769 | 99.6% | C28H32N2O7 | 10MG
Indacaterol maleate is the maleate salt of indacaterol, an ultra-long-acting β2-adrenergic receptor agonist. This product is supplied as an analytical reference standard for research and laboratory use and is intended for assay development, method validation, and quality control (not for human use).
- High-purity reference material (HPLC 99.62%).
- Suitable for assay development and method validation.
- Intended for research and analytical use only.
- Supplied as a stable solid for standard preparation.
- Identified by CAS 753498-25-8 for unambiguous reference.
eMolecules Ambeed Benzyl propiolate 250mg 784395630 A332728 0 000 14447-01-9 MFCD11976128 160 172 C10H8O2
Ambeed Benzyl propiolate 250mg 784395630 A332728 0 000 14447-01-9 MFCD11976128 160 172 C10H8O2
eMolecules Harringtonine | 26833-85-2 | MFCD28978177 | 250mg
Combi-Blocks, Inc. | Harringtonine | 250mg | 603142371 | HD-9179 | 95.000 | 26833-85-2 | MFCD28978177 | 531.602 | C28H37NO9
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Medchemexpress LLC E7766 diammonium salt | 2242635-03-4 | 99.5% | 780.66 | C24H32F2N12O8P2S2 | 5 MG
E7766 diammonium salt is a macrocycle-bridged stimulator of interferon genes (STING) agonist that binds STING with high affinity (Kd ≈ 40 nM) and has shown potent pan-genotypic activation and antitumor efficacy in preclinical studies. The compound is supplied as the diammonium salt for research applications and is provided at high reported purity with recommended frozen storage to preserve stability.
- Macrocycle-bridged STING agonist with high affinity (Kd ≈ 40 nM).
- Demonstrated pan-genotypic STING activation and antitumor activity in preclinical models.
- Supplied as a diammonium salt with high purity (≈99.5%).
- Molecular weight 780.66 g·mol-1; formula C24H32F2N12O8P2S2.
- Recommended storage at -20°C to maintain stability for research use.
Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.9% | 603.60 | 100 MG
Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects.
- Third-generation, irreversible and orally active selective EGFR inhibitor.
- Potent inhibition of EGFR L858R (IC50: 0.18 nM), EGFR T790M (IC50: 0.18 nM), and wild-type EGFR (IC50: 7.68 nM).
- BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma.
- Exhibits anticancer effects.
- Selectively inhibits mutant EGFR phosphorylation.
- Inhibits phosphorylation of downstream targets Akt and ERK1/2 in NCI-H1975 and HCC827 cells.
- Inhibits EGFR-mutant tumor growth in xenograft models over extended duration.
Medchemexpress LLC PD-168077 maleate | 630117-19-0 | 99.6% | 450.49 | 100 MG
PD-168077 maleate is a selective dopamine D4 receptor agonist with a Ki of 9 nM. It is for research use only. It shows high selectivity over other D2-like receptor family members and D1-like counterparts, as well as α1, α2, 5-HT1A, and 5-HT2A receptors. It evidences intrinsic activity at the D4 receptor and can induce locomotion in a dose-dependent manner. This product may be used in research related to neurological diseases, neurodegenerative diseases, depression, and Parkinson's disease.
- Selective dopamine D4 receptor agonist
- High selectivity over other receptor types
- Evidences intrinsic activity at the D4 receptor
- Induces locomotion in PD-168077-treated cells
- May be used in research for neurological diseases
AdipoGen Ganglioside GD1b 2Na bovine
Chemical. CAS 19553-76-5. Formula C84H146N4O39 . 2Na. MW 1836.1 . 46.0 calculated on sphingosine C181 and stearic acid. Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1b may act as a bacterial toxin receptor tetanus, botulinus. High levels are found in gliomas and astrocytomas. It modulates protein kinase activities. In vivo and in vitro it is in equilibrium with the lactone structure.
Medchemexpress LLC Velnacrine maleate | 118909-22-1 | HY-W011246 | 98.0% | 330.34 | 100 MG
Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.
- Orally active
- Cholinesterase inhibitor
- Used for research of Alzheimer's disease
Medchemexpress LLC IMMH-010 maleate | 2541982-47-0 | 99.8% | 756.04 | 1 MG
IMMH-010 maleate is a prodrug that serves as a novel PD-L1 inhibitor, exhibiting potential antitumor activity for the treatment of neurological disorders and advanced malignant solid tumors. It is rapidly converted to its active form, YPD-29B, following oral administration. IMMH-010 maleate is poised for advancing research in the field of PD-L1 inhibitors and related therapeutic applications.
- Novel PD-L1 inhibitor
- Exhibits potential antitumor activity for neurological disorders and advanced malignant solid tumors
- Prodrug that rapidly converts to its active form, YPD-29B, following oral administration
- Poised for advancing research in the field of PD-L1 inhibitors and related therapeutic applications
Apexbio Technology LLC WAY-100635 maleate salt 1092679-51-0 100mg
WAY-100635 maleate salt (CAS 1092679-51-0) is a selective antagonist of the serotonin 5-HT1A receptor subtype It demonstrates high potency with a reported pIC50 value of 8 87 and displays over 100-fold selectivity relative to other serotonin receptor isoforms and common neurotransmitter receptor classes Due to its specific interaction with 5-HT1A receptors WAY-100635 maleate is frequently applied in neuroscience research to elucidate serotonin-mediated pathways and associated physiological or behavioral responses
Medchemexpress LLC Pirepemat fumarate | 2251806-70-7 | 98.3% | C15H17F2NO5 | 10MG
Pirepemat fumarate is the fumarate salt of pirepemat (IRL752), a cortical-preferring catecholamine- and cognition-promoting research compound investigated for reducing falls and improving cognitive and motor function in Parkinson's disease. The compound is provided as a stable fumarate salt and is used in preclinical and clinical research to modulate cortical neurotransmitter signaling.
- Fumarate salt for improved chemical stability.
- Cortical-preferring catecholamine and cognition-promoting activity.
- Investigated for reduction of falls and improvement of balance in Parkinson's disease.
- Shown to enhance cortical dopamine, acetylcholine, and norepinephrine transmission.
- Supplied in solid and DMSO solution formats for flexible dosing and formulation.
- High purity suitable for research applications.