Carboxylic acids and derivatives
Medchemexpress LLC Nomifensine maleate | 32795-47-4 | 98.7% | 100 MG
Nomifensine maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. It inhibits the uptake of NE, DA, and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM, and 830 nM, and Ki values of 4.7 nM, 26 nM, and 4000 nM, respectively. It demonstrates antidepressant and analgesic effects and is utilized in research pertaining to neurodegenerative diseases, compound addiction, and pain.
- Reduces response latency and increases activity in WKY rats.
- Significantly inhibits dopamine neuronal firing in the ventral tegmental area of SD rats.
- Produces analgesia in the formaldehyde test.
- Suppresses neurotoxicity induced by MPTP.
Medchemexpress LLC Cipralisant maleate | 223420-20-0 | 99.8% | 332.4 g/mol | C18H24N2O4 | 5 MG
Cipralisant maleate is the maleate salt of cipralisant, a potent and selective histamine H3 receptor ligand that functions as a full antagonist in vivo and an agonist in vitro. Supplied for research use in neuroscience and pharmacology, the compound offers high purity, good DMSO solubility, and defined storage conditions for stability.
- Potent, selective histamine H3 receptor antagonist in vivo.
- Agonist activity observed in vitro.
- High reported purity (99.84%).
- Soluble in DMSO at ≥ 100 mg/mL.
- Molecular weight 332.4 g/mol.
- Recommended storage: powder -20°C for long term, 4°C for short term.
eMolecules ChemScene / (Chloromethyl)triethoxysilane / 5g / 536799853 / CS-0086574 / 0.000 / 15267-95-5 / MFCD00039354 / 212.750 / C7H17ClO3Si
ChemScene / (Chloromethyl)triethoxysilane / 5g / 536799853 / CS-0086574 / 0.000 / 15267-95-5 / MFCD00039354 / 212.750 / C7H17ClO3Si
Medchemexpress LLC Sumanirole (maleate) | 179386-44-8 | 99.8% | C15H17N3O5 | 25 MG
Sumanirole maleate (U-95666E; PNU-95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. It plays an important role in the research of Parkinson's disease and restless leg syndrome. Sumanirole is a valuable tool compound for basic research to identify neurobiological mechanisms based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.
- Highly selective D2 receptor full agonist
- ED50 of about 46 nM
- Valuable tool for identifying neurobiological mechanisms
- Used in research for Parkinson's disease
- Used in research for restless leg syndrome
TARGETMOL CHEMICALS INC Ro 25-6981 Maleate 25MG
Also available in 1 mL, 1 mg, 5 mg, 10 mg and bulk. Please contact Fisher for quotes. Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 uM for NR1C/NR2B and 52 uM for NR1C/NR2A receptor subunit combinations). Purity 99.42%
TARGETMOL CHEMICALS INC Thioperamide maleate 10MG
Also available in 1 mL, 1 mg, 5 mg, 25 mg and bulk. Please contact Fisher for quotes. Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM). Purity 99.88%
Selleck Chemical LLC CarbinoxaMine Maleate S4696-100mg
Carbinoxamine maleate is a histamine-H1 receptor blocking agent with antihistamine and anticholinergic properties
Selleck Chemical LLC Vicriviroc maleate S3494-5mg
Vicriviroc maleate(SCH-417690 maleate SCH-D maleate) is a potent selective oral bioavailable and CNS penetrated antagonist of CCR5 with a Ki of 2 5 nM and also inhibits HIV-1 in PBMC cells
Selleck Chemical LLC (-)-Dizocilpine (MK 801) Maleate S2857-50mg
(-)-Dizocilpine (MK 801 Dizocilpine C13737) Maleate is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30 5 nM
Selleck Chemical LLC Pixantrone Maleate S5059-10mg
Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites
Selleck Chemical LLC Dimethindene maleate-100MG
Dimethindene maleate is a selective antagonist of histamine H1 and exhibits antihistamine effects It suppresses the cromakalim-induced/glibenclamide-sensitive K currents in a concentration-dependent and reversible manner
Medchemexpress LLC Zamifenacin fumarate | 127308-98-9 | 99.0% | 531.60 g/mol | C31H33NO7 | 5 MG
Zamifenacin fumarate is the fumarate salt of zamifenacin (UK-76654), a gut-selective muscarinic M3 receptor antagonist used in research to study gastrointestinal motility. It is provided as a high-purity solid for use in in vitro and in vivo pharmacology studies targeting colonic motility.
- Potent gut-selective muscarinic M3 receptor antagonist that reduces colonic motility.
- High purity suitable for research applications (99.0%).
- Solid, white to off-white form for convenient handling and dosing.
- Molecular weight 531.60 g/mol, molecular formula C31H33NO7.
- Recommended storage at 4°C; in solution, -80°C for long-term stability.
Medchemexpress LLC Tegaserod maleate | 189188-57-6 | 99.9% | C20H27N5O5 | 50 MG
Tegaserod maleate is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. This compound induces tumor cell apoptosis, attenuates PI3K/Akt/mTOR signaling, and reduces S6 phosphorylation. It demonstrates anti-tumor activity and is being investigated for its potential in irritable bowel syndrome (IBS) research.
- Orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist
- 5-HT2B receptor antagonist
- Induces tumor cell apoptosis
- Attenuates PI3K/Akt/mTOR signaling
- Reduces S6 phosphorylation
- Demonstrates anti-tumor activity
- Potential for irritable bowel syndrome (IBS) research
- For research use only
Medchemexpress LLC Edonerpic (maleate) | 519187-97-4 | 99.8% | 407.48 | 25 MG
Edonerpic maleate is a novel neurotrophic agent that inhibits amyloid-β peptides (Aβ). It has been shown to preserve cortical neurons in the presence of Aβ(1-42) and prevent oxidative stress-induced neuronal death.
- Prevents oxidative stress-induced neuronal death.
- Almost completely prevents GSH reduction.
- Significantly increases neurite length in hippocampal slices.
- Ameliorates deficits in adult neurogenesis and spatial memory in rats.