Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. It inhibits IL-17 production by CD4 T cells stimulated with IL-15 and enhances TP53, DMD, and COL17A1 PTC readthrough by G418. This compound significantly sensitizes multidrug resistance tumors by inducing G2/M phase arrest and apoptosis when used with low-dose Paclitaxel, making it suitable for research on rheumatoid arthritis and cancer.
- Potent, orally active immunomodulator
- Inhibits IL-17 production by CD4 T cells
- Enhances PTC readthrough for TP53, DMD, and COL17A1
- Increases cellular protein levels and synthesis
- Sensitizes multidrug resistance (MDR) tumors
- Induces G2/M phase arrest and apoptosis
- Ameliorates collagen-induced arthritis (CIA)
- Used in research for rheumatoid arthritis and cancer