Azoles
![Medchemexpress LLC 1H-pyrazole-1-acetamide, 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo | 1282512-48-4 | MFCD26142641 | 99.8% | 460.53 g·mol⁻¹ | C24H28N8O2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00132390-MCE-LOGO.JPG-250.jpg){kind=logo}
Medchemexpress LLC 1H-pyrazole-1-acetamide, 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo | 1282512-48-4 | MFCD26142641 | 99.8% | 460.53 g·mol⁻¹ | C24H28N8O2 | 5 MG
Taselisib (GDC-0032) is a potent small-molecule inhibitor of phosphoinositide 3-kinase (PI3K) used in preclinical research to probe PI3K signaling and PIK3CA-driven pathways. It displays high biochemical potency across PI3K isoforms and is provided as a research-grade compound for in vitro and in vivo studies.
- Potent inhibition of PI3Kα with Ki ≈ 0.29 nM.
- Sub-nanomolar activity versus PI3Kδ and PI3Kγ; low-nanomolar versus PI3Kβ.
- High purity suitable for biological assays (99.8% LCMS).
- Stable powder with recommended storage at -20°C; solutions stable at -80°C.
- Molecular weight 460.53 g·mol⁻¹; chemical formula C24H28N8O2.
Apexbio Technology LLC (±)-Decanoylcarnitine chloride 14919-36-9 50mg
racemic Baclofen -Decanoylcarnitine chloride is a small-molecule modulator targeting cholinergic systems by engaging acetylcholine receptors including nicotinic and muscarinic subtypes It is designed to influence neurotransmission and lipid metabolism racemic Baclofen -Decanoylcarnitine chloride exerts its biological activity primarily through modulation of acetylcholine receptors and inhibition of -aminobutyric acid (GABA) receptor activity thereby attenuating GABA-mediated inhibitory synaptic currents In neuronal cells and cardiac models such acylcarnitine derivatives demonstrate antiarrhythmic properties post-ischemic insult and modulation of pain signaling involving the phospholipase C-inositol triphosphate pathway Based on these pharmacological properties racemic Baclofen -Decanoylcarnitine chloride holds research potential in cardiac arrhythmia and pain modulation applications
Medchemexpress LLC 1H-Pyrazole-1-carboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester | 552846-17-0 | 294.16 | 10 G
1-Boc-pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
- Suitable for life science related research
- Functions as a biochemical reagent
- Can be used as a biological material
- Can be used as an organic compound
- For research use only
- Tested and complies with specifications
Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 100 MG
JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It exhibits an IC50 of 2 nM for EML4-ALK G1202R in cells and potently inhibits various other EML4-ALK mutants and wild type (e.g., EML4-ALKwt, EAC1156Y, EAF1174L, EAS1206Y with IC50s of 2-196 nM). It shows selectivity at other kinases like IRAK1, CLK4, RET, and IRAK 4. JH-VIII-157-02 demonstrates inhibitory growth against cancer cell lines like H3122 and DFCI76 (EC50s of 5 nM and 19 nM). It also has good oral bioavailability and penetrates the CNS in mice.
- Structural analogue of alectinib
- Acts as an ALK inhibitor
- Shows potent inhibition of EML4-ALK G1202R mutant (IC50 of 2 nM)
- Potently inhibits other EML4-ALK mutants and wild type
- Exhibits selectivity at several other kinases
- Inhibits growth of cancer cell lines
- Good oral bioavailability in mice
- Penetrates the CNS of mice
Chem-Impex International, Inc. Thiazole-2-carboxylic acid | 14190-59-1 | MFCD02094169 | 1G
Thiazole-2-carboxylic acid, 14190-59-1, MFCD02094169, 1G