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Atopaxar is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. As an antiplatelet agent, it interferes with platelet signaling and can be used for the research of atherothrombotic disease.
Potent, orally active, selective and reversible PAR-1 antagonist
Interferes with platelet signaling
Used for research of atherothrombotic disease
Inhibits human platelet aggregation induced by thrombin or TRAP
Does not inhibit PRP aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to 20 μM
Causes dose-dependent prolongation of time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model
Does not prolong bleeding time in guinea pigs at high dosages
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Methyl clofenapate (Clofenapate methyl ester; MCP) is a peroxisome proliferator that can induce hypolipidemia, peroxisome proliferation, and hepatocarcinogenesis. This compound appears as a white to off-white solid. It has been tested and complies with given specifications.
Appearance: White to off-white solid
Storage conditions for powder: -20°C for 3 years, 4°C for 2 years
Storage conditions in solvent: -80°C for 6 months, -20°C for 1 month
1H NMR spectrum consistent with structure
LCMS consistent with structure
For research use only
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Medchemexpress, HY-101524 100mg TC13172 CAS:2093393-05-4 TC13172 is a mixed lineage kinase domain-like protein ( MLKL ) inhibitor with an EC 50 value of 2 nM for HT-29 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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