Azoles
Apexbio Technology LLC Y-320 288250-47-5 10mg
Y-320 (CAS 288250-47-5) is a phenylpyrazoleanilide small molecule immunomodulator that inhibits interleukin-17 (IL-17) production in CD4 T cells stimulated by IL-15 exhibiting an IC50 of 20 60 nM In vivo oral administration of Y-320 (0 3 3 mg/kg) reduces IL-17 mRNA expression and suppresses the progression of collagen-induced arthritis (CIA) in mice with additional efficacy observed in cynomolgus monkey CIA models Combination with anti-TNF- monoclonal antibody yields a synergistic effect Y-320 serves as a valuable tool for studying IL-17-mediated inflammatory pathways and for preclinical research in rheumatoid arthritis and related autoimmune diseases
Medchemexpress LLC CA-170 10mg
CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1 CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes1]2]
Medchemexpress LLC Urocanic acid | 104-98-3 | 99.9% | 138.13 | 1 G
Urocanic acid is an endogenous metabolite found in the upper layers of mammalian skin. It serves as a significant absorber of ultraviolet radiation (UVR), playing a role in the skin's natural defense mechanisms. In vitro studies indicate its formation through the breakdown of filaggrin by proteinases.
- Produced in upper layers of mammalian skin
- Acts as a major absorber of ultraviolet radiation (UVR)
- Formed from filaggrin breakdown in the epidermis
- For research use only
Medchemexpress LLC Cis-urocanic acid | 7699-35-6 | 99.9% | 138.12 | 1 MG
cis-Urocanic acid is a 5-HT2A receptor agonist that binds to the 5-HT receptor with relatively high affinity (Kd=4.6 nM). This compound acts as an immune modulator, inducing immunosuppression through its binding to the 5-HT2A receptor.
- 5-HT2A receptor agonist.
- Immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
- Treatment with 100 μg/mL completely suppresses IL-6 and IL-8 secretion.
- Decreases caspase-3 activity.
- Improves cell viability against UV-B irradiation in human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs).
eMolecules ChemScene / Ethyl 2-(4-ethynylphenyl)acetate / 100mg / 795362632 / CS-0434273 / 0.000 / 87356-23-8 / MFCD13194555 / 188.226 / C12H12O2
ChemScene / Ethyl 2-(4-ethynylphenyl)acetate / 100mg / 795362632 / CS-0434273 / 0.000 / 87356-23-8 / MFCD13194555 / 188.226 / C12H12O2
Medchemexpress LLC Imidazoleacetic acid | 645-65-8 | 99.8% | 126.11 | 50 MG
Imidazoleacetic acid is a blood-brain barrier-permeable full agonist of the GABAA receptor. It forms via histamine oxidation in the mouse brain and exerts multiple neurochemical and behavioral effects. It induces centrally mediated effects such as analgesia, sedation, hypnosis, and reductions in blood pressure, body temperature, isolation-induced aggression, and motor activity.
- Human endogenous metabolite
- Initial source: endogenous metabolite human gut microbiota metabolites
Medchemexpress LLC Fludarabine chloride | 2734853-80-4 | 99.7% | 303.68 g/mol | C10H11ClFN5O3 | 5 MG
Fludarabine chloride is a research-grade nucleoside analogue used in biochemical and cellular studies. It inhibits RNA adenosine deaminase 1 (ADAR1) with reported in vitro activity and is supplied in solid and solution formats for laboratory research. Typical applications include RNA-editing assays, cancer-related cellular studies, and inhibitor screening.
- Inhibits ADAR1 with reported IC50 ≈ 0.87 μM.
- Available as solid and as a 10 mM solution for flexible use.
- High reported purity suitable for research applications.
- Supplied in small research quantities for assay development.
- Suitable for cellular assays and biochemical inhibition studies.
Cayman Chemical DihomoLinolenic Acid methyl
The methyl ester of an intermediate in the synthesis of arachidonic acid
eMolecules Ambeed / 2-Nitrothiazole / 250mg / 758385805 / A789939 / / 1606-76-4 / MFCD01760316 / 130.120 / C3H2N2O2S
Ambeed / 2-Nitrothiazole / 250mg / 758385805 / A789939 / / 1606-76-4 / MFCD01760316 / 130.120 / C3H2N2O2S
Medchemexpress LLC 1h-Imidazole-4-carboxylic acid | 1072-84-0 | 112.09 | 5 G
1H-Imidazole-4-carboxylic acid is an organic compound featuring an imidazole ring and a carboxyl group. It stabilizes specific forms of metal ions through coordination, influencing chemical reactions. This compound plays a role in the hydrolysis of phosphate esters catalyzed by lanthanide metals and can modify dendrimers to alter surface properties and catalytic performance.
- Stabilizes specific forms of metal ions
- Influences chemical reactions
- Role in hydrolysis of phosphate esters catalyzed by lanthanide metals
- Can modify dendrimers to change surface properties
- Can modify dendrimers to change catalytic performance
Medchemexpress LLC 3-Methylpyrazole | 1453-58-3 | 99.5% | C4H6N2 | 5 G
This product is 3-Methylpyrazole, a chemical compound primarily used as a nitrification inhibitor in soil. It also demonstrates the ability to inhibit the metabolism of methylazoxymethanol (MAM) by rat liver microsomes.
- Used as a nitrification inhibitor in soil
- Inhibits MAM metabolism by rat liver microsomes
- Appearance: Light yellow to reddish brown
- Purity (HPLC): 99.5%
- Store pure form at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Soluble in H2O (25 mg/mL) and PBS (50 mg/mL)
eMolecules 2-(2-Aminophenyl)thiazole-4-carboxylic acid ethyl ester | 658076-43-8 | MFCD06738348 | 1g
Chem-Impex | 2-(2-Aminophenyl)thiazole-4-carboxylic acid ethyl ester | 1g | 386896351 | 18541 | | 658076-43-8 | MFCD06738348 | 248.300 | C12H12N2O2S
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