Azoles
Medchemexpress LLC (4S)-PROTAC SOS1 degrader-1 | 2913176-81-3 | C57H76ClFN10O4S | 50 MG
(4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader. It decreases the expression of pERK and RAS-GTP levels in a dose-dependent manner. It also significantly inhibits tumor growth in vivo.
- Shows potent SOS1 degradation activity with 56.2% and 92.5% SOS1 protein degradation at 0.1 and 1 μM, respectively, in NCI-H358 cells.
- Degrades SOS1 in a dose- and time-dependent manner in NCI-H358 cells (24 h incubation).
- Does not induce SOS2 and KRAS degradation in NCI-H358 cells (9.8-2500 nM; 24 h).
- Decreases the expression of pERK and RAS-GTP levels in NCI-H358 cells in a dose-dependent manner (7.8-2000 nM; 24 h).
- Significantly inhibits tumor growth in vivo.
Medchemexpress LLC (2S,4S)-pyrrolidine-2-carboxamide derivative (diTFA) | 00-00-0 | 98.1% | 1279.84 g·mol⁻¹ | C61H78ClF7N10O8S | 5 MG
(4S)-PROTAC SOS1 degrader-1 (diTFA) is a research-grade PROTAC designed to induce targeted degradation of the SOS1 protein in cellular studies. It reduces SOS1 levels and downstream signaling pathways such as pERK and RAS-GTP, and is supplied as a TFA salt for preclinical research applications.
- Potent SOS1 degrader in cell-based assays.
- Reduces pERK and RAS-GTP signaling.
- High purity (~98.1%).
- Molecular weight 1279.84 g·mol⁻¹.
- Supplied as a 5 mg vial for research use.
- Certificate of analysis and safety data sheet available.
- Store at -20 °C, sealed, to preserve stability.
![Medchemexpress LLC 5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one | 1800477-35-3 | 96.9% | 327.38 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402937-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one | 1800477-35-3 | 96.9% | 327.38 | 250 MG
This chemical is 5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one, identified for use as a laboratory chemical and in the manufacture of substances.
- Used as a laboratory chemical.
- Used in the manufacture of substances.
- Off-white to light yellow solid.
- Recommended storage conditions for powder and in solvent.
- For research use only.
eMolecules 33123-73-8 | Ambeed | Ethyl 45-dimethyloxazole-2-carboxylate | 100mg | 600834719 | A232181 | MFCD22689290 | 169.18 | C8H11NO3
ChemScene | (3-Cyclopropoxyphenyl)boronic acid | 100mg | 569147013 | CS-0135502 | 808140-97-8 | MFCD16996193 | 177.990 | C9H11BO3
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eMolecules 811-93-8 | 1,1-DIMETHYL-1,2-ETHANEDIAMINE | AstaTech | MFCD00008054 | 88.154 | C4H12N2 | 95.000 | CC(C)(N)CN | 25g | 553400325
1,1-DIMETHYL-1,2-ETHANEDIAMINE | AstaTech | 811-93-8 | MFCD00008054 | 88.154 | C4H12N2 | 95.000 | CC(C)(N)CN | 25g | 553400325
Medchemexpress LLC (4S)-GLP-1 receptor agonist 14 | 2758659-09-3 | 99.6% | 880.94 | 25 MG
(4S)-GLP-1 receptor agonist 14 is a potent and orally active GLP-1 receptor agonist with an EC50 ≤ 20 nM. It can be used for research on diabetes, obesity, metabolic diseases, cardiovascular diseases, liver diseases, nonalcoholic steatohepatitis (NASH), and other diseases associated with the GLP-1 receptor.
- Potent and orally active GLP-1 receptor agonist
- EC50 ≤ 20 nM
- Applicable for research on various diseases including diabetes, obesity, metabolic diseases, cardiovascular diseases, liver diseases, and nonalcoholic steatohepatitis (NASH)