AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor, with an IC50 of 0.07 μM. It is for research use only and demonstrates dose-dependent inhibition of the mutant IDH1 enzyme in TS603 glioma cells. AGI-5198 can also reverse the effects of increased reactive oxygen species, DNA double-strand breaks, and cell death in IDH1(R132H) mutated cancer cells after exposure to ionizing radiation. In vivo studies show it causes 50 to 60% growth inhibition of human glioma xenografts.
- Solid appearance with a white to off-white color
- Inhibits IDH1R132H mutant with an IC50 of 0.07 μM
- Soluble in DMF and DMSO for in vitro applications
- Available in powder and solvent forms for varied storage conditions
- Demonstrates significant growth inhibition in human glioma xenografts