Imidazoleacetic acid is a blood-brain barrier-permeable full agonist of the GABAA receptor. It is formed via histamine oxidation in the mouse brain. It exerts multiple neurochemical and behavioral effects, including analgesia, sedation, hypnosis, and reductions in blood pressure, body temperature, isolation-induced aggression, and motor activity.
- Blood-brain barrier-permeable full agonist of the GABAA receptor
- Forms via histamine oxidation in the mouse brain
- Exerts multiple neurochemical and behavioral effects
- Acts as an agonist at human GABAC rho 1 receptor
- Exhibits partial agonist activity against rho-1 and rho-2 subunit GABA-C receptor in oocytes
- Also an agonist on human Gamma-aminobutyric acid A receptor