Azoles
Medchemexpress LLC Cis-urocanic acid-13c3 | 7699-35-6 | 99.5% | 139.09 | 1 MG
cis-Urocanic acid-13C3 is the 13C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist and an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor with a relatively high affinity (Kd=4.6 nM).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
Medchemexpress LLC Cis-urocanic acid | 7699-35-6 | 99.9% | 138.12 | 1 MG
cis-Urocanic acid is a 5-HT2A receptor agonist that binds to the 5-HT receptor with relatively high affinity (Kd=4.6 nM). This compound acts as an immune modulator, inducing immunosuppression through its binding to the 5-HT2A receptor.
- 5-HT2A receptor agonist.
- Immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
- Treatment with 100 μg/mL completely suppresses IL-6 and IL-8 secretion.
- Decreases caspase-3 activity.
- Improves cell viability against UV-B irradiation in human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs).
Medchemexpress LLC Norvancomycin (monohydrochloride) | 213997-73-0 | 95.3% | 1 ML
Norvancomycin monohydrochloride is a cell wall synthesis inhibitor, targeting peptidoglycan precursors of Gram-positive bacteria. It irreversibly inhibits bacterial cell wall synthesis, showing antibacterial activity. Primarily used for Gram-positive bacterial infections like MRSA and MRSE, it can also be incorporated into bionic calcium phosphate coatings on titanium implants to enhance antibacterial activity and prevent postoperative orthopedic infections.
- Targets peptidoglycan precursors of Gram-positive bacteria
- Cannot pass the blood-brain barrier
- Inhibits bacterial cell wall synthesis
- Effective against Gram-positive bacterial infections (MRSA, MRSE)
- Enhances antibacterial activity in titanium implant coatings
- Inhibits Staphylococcus aureus in in vitro studies
- Widely distributed in rat tissues (not in brain)
Medchemexpress LLC Imidazoleacetic acid hydrochloride | 3251-69-2 | MFCD00060175 | 162.58 | 1 ML
Imidazoleacetic acid hydrochloride is a γ-aminobutyric acid receptor agonist. It acts as a non-competitive inhibitor of GABA-T, with a Ki value of 0.34 mM. This compound has been shown to increase the total free GABA (gamma-aminobutyric acid) in the brain and is intended for research use only. In vitro studies demonstrate that imidazoleacetic acid (3 mM) hydrochloride inhibits GABA-T in a non-competitive manner, with a Ki value of 0.34 mM. In vivo, when administered at 400 mg/kg (i.p.; single dose), it increases the total free GABA pool size in mouse brain without a concomitant increase in GABA biosynthesis from glutamate.
- Acts as a γ-aminobutyric acid receptor agonist
- Non-competitive inhibitor of GABA-T
- Increases total free GABA in the brain
- Intended for research use only
BLD PHARMATECH CO LIMITED DPZ, CAS Number: 1818245-74-7, 1g, Purity: 95%
DPZ, CAS Number: 1818245-74-7, 1g, Purity: 95%
Medchemexpress LLC IL-2R beta/CD122 Ca 50ug | 50ug
IL-2R beta (CD122) a type cytokine receptor expressed on T lymphocytes is a receptor for IL-2 (Kd 1 nM approximately)[1] IL-2R beta mediates T cell immune responses such as stimulating T cell proliferation and activating lymphokine-activated killer cells[2] IL-2R beta/CD122 Protein Canine (HEK293 His) is a recombinant canine IL-2R betawith a C-Terminal His tag which is produced in HEK293 cells
![Medchemexpress LLC L-threonine, N-[[[1S-3-amino-1-[3-[1R-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl] | 1673534-76-3 | 360.32 | C12H20N6O7 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211835.png-250.jpg)
Medchemexpress LLC L-threonine, N-[[[1S-3-amino-1-[3-[1R-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl] | 1673534-76-3 | 360.32 | C12H20N6O7 | 100 MG
CA-170 is a small-molecule dual inhibitor of the immune checkpoints VISTA and PD-L1 developed for preclinical research. It modulates T-cell proliferation and effector functions suppressed by PD-L1/L2 and VISTA, and is used to study immune checkpoint pathways in vitro and in vivo.
- Dual inhibitor of VISTA and PD-L1
- Orally active small-molecule suitable for preclinical studies
- Modulates T-cell proliferation and effector functions
- Defined chemical properties to support reproducibility
- Storage recommendations provided for powder and solutions
- Intended for research use only
Medchemexpress LLC Methyl pentadecanoate | 7132-64-1 | 256.42 | 1 ML
Methyl pentadecanoate is a fatty acid ester that can be isolated from *L. wallichi* extracts. It is obtained by the condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol. This product is for research use only.
- Appearance: Solid-liquid mixture
- Color: Colorless to light yellow
- Structure classification: Lipid
- Initial source: Plants (other families)
- Store at room temperature for 3 years
- Store in solvent at -80°C for 2 years, or -20°C for 1 year
Medchemexpress LLC Ca(II)-EDTA (disodium dihydrate) | 6766-87-6 | 98.0% | 410.30 | C10H12CaN2O8·2Na·2H2O | 5g
Ca -EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans Prevotella intermedia and Porphyromonas gingivalis[1] Ca -EDTA disodium dihydrate is effective chelating antidotes for lead-and cadmium poisoning[2][3]
Medchemexpress LLC 1h-Imidazole-4-carboxylic acid | 1072-84-0 | 112.09 | 5 G
1H-Imidazole-4-carboxylic acid is an organic compound featuring an imidazole ring and a carboxyl group. It stabilizes specific forms of metal ions through coordination, influencing chemical reactions. This compound plays a role in the hydrolysis of phosphate esters catalyzed by lanthanide metals and can modify dendrimers to alter surface properties and catalytic performance.
- Stabilizes specific forms of metal ions
- Influences chemical reactions
- Role in hydrolysis of phosphate esters catalyzed by lanthanide metals
- Can modify dendrimers to change surface properties
- Can modify dendrimers to change catalytic performance
Medchemexpress LLC Pyridine-3,5-dicarboxylic acid | 499-81-0 | 167.12 | 25 G
Pyridine-3,5-dicarboxylic acid is a drug intermediate that can be used to construct new metal-organic framework materials. This compound is suitable for various laboratory applications.
- Used as a drug intermediate
- Can be used to construct new metal-organic framework materials
- White to off-white solid appearance
- High purity for reliable results