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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
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GP531 is a potent, second-generation adenosine regulating agent. It is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia. It is effective at lower doses in reducing ischemic/reperfusion injury severity without inducing adverse hemodynamic effects.
Reduces infarct size and anatomic no-reflow zone in rabbits
Effective at lower doses in reducing ischemic/reperfusion injury severity
Does not induce adverse hemodynamic effects like bradycardia and hypotension
Decreases left ventricular end-diastolic pressure, end-diastolic volume, end-systolic volume, and end-diastolic wall stress in dogs with heart failure
Increases left ventricular ejection fraction without increasing myocardial oxygen consumption
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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DIM-C-pPhOH (CAS 151358-47-3) is a small-molecule antagonist that targets the nuclear receptor NR4A1 (nuclear receptor subfamily 4 group A member 1) It has been shown to inhibit tumor cell proliferation by modulating the mTOR signaling pathway induce apoptosis and activate cellular stress responses In in vitro studies using human renal carcinoma cell lines ACHN and 786-O DIM-C-pPhOH demonstrated inhibitory effects on cell proliferation with IC50 values of 13 6 M and 13 0 M respectively This compound serves as a valuable tool for investigating tumor-associated signaling pathways and the mechanisms underlying anticancer therapeutics
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