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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
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NDT 9513727 is a potent, selective, orally active, and competitive inverse agonist of the human C5aR (C5a receptor), with an IC50 of 11.6 nM. It can be used for the research of human inflammatory diseases.
Potent and selective inverse agonist of human C5aR.
Orally active and competitive.
Inhibits C5a-stimulated responses such as Ca2+ mobilization, oxidative burst, and chemotaxis.
Exhibits dose-dependent inhibition of hC5a-induced neutropenia.
Moderate oral bioavailability and plasma elimination half-lives.
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