Apexbio Technology LLC ODQ 41443-28-1 10mg
ODQ (CAS 41443-28-1) is a selective inhibitor of soluble guanylate cyclase (sGC) interfering with nitric oxide (NO)-dependent intracellular signaling by blocking sGC-mediated catalysis of cyclic guanosine monophosphate (cGMP) synthesis This inhibition results in reduced cGMP production and subsequent modulation of protein kinase G-regulated cellular processes Studies have demonstrated that ODQ enhances cisplatin-induced apoptosis in human mesothelioma cells in vitro supporting its use in investigating tumor cell apoptosis mechanisms and evaluating synergistic effects in anticancer drug research