GAL-02-221 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. It can potently degrade BRD4 in HER2 positive and negative breast cancer cell lines.
- Potently degrades BRD4
- Degrades BRD4 in HER2 positive and negative breast cancer cell lines
- Connected by ligands for von Hippel-Lindau and BRD4
- Shows antiproliferative activity against human 22Rv1, L02, MCF7, and MDA-MB-231 cells