TH-Z145 is a lipophilic bisphosphonate that functions as an FPPS inhibitor with an IC50 of 210 nM. It has shown promising effects in preclinical studies, including strong prophylactic effects in pathogenic influenza models and inhibition of tumor growth in xenograft mouse models.
- Exhibits strong prophylactic effects in pathogenic influenza models
- Inhibits tumor growth and prolongs survival in B16-OVA xenograft mouse models
- Functions as an FPPS inhibitor with an IC50 of 210 nM
- Appears as an off-white to light yellow solid
- Soluble in DMSO at 100 mg/mL
- Not classified as a hazardous substance or mixture