VH-298 is a cell-permeable inhibitor of the VHL:HIF-α interaction that induces HIF-α accumulation and serves as an E3 ligase ligand for PROTAC synthesis. It is potent (Kd 80-90 nM), shows minimal off-target activity in broad panels, and is suitable as a chemical probe for studying hypoxic response and targeted protein degradation.
- Highly potent VHL:HIF-α interaction inhibitor (Kd 80-90 nM).
- Induces HIF-α accumulation in human cell lines.
- Functions as an E3 ligase ligand for PROTAC synthesis.
- Cell-permeable with low cellular toxicity.
- Minimal off-target activity across kinase, GPCR, and ion channel panels at 50 μM.
- High purity and defined storage and solubility profiles for experimental use.