Azoles
Medchemexpress LLC 2-acetylthiazole | 24295-03-2 | MFCD00005324 | 99.5% | 127.16 g/mol | C5H5NOS | 50g
2-Acetylthiazole (1-(1 3-Thiazol-2-yl)ethanone 1-(Thiazol-2-yl)ethanone Methyl 2-thiazolyl ketone) is a flavor compound 2-Acetylthiazole is a kind of biological materials or organic compounds that are widely used in life science research[1]
Medchemexpress LLC (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone | 141627-42-1 | 99.6% | C20H19NO5 | 25 G
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone is a drug intermediate for the synthesis of various active compounds. It is for research use only.
- Used as a drug intermediate for active compound synthesis
- Molecular weight: 353.37
- Chemical formula: C20H19NO5
- Appearance: Solid, yellow to brown
- Shipping: Room temperature in continental US
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
![Apexbio Technology LLC Cytochrome P450 CYP1B1 (190-198) [Homo sapiens] 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096433.png-250.jpg)
Apexbio Technology LLC Cytochrome P450 CYP1B1 (190-198) [Homo sapiens] 5mg
Cytochrome P450 CYP1B1 190-198 is a tumor-associated antigen peptide derived from CYP1B1 It is designed to induce HLA-A2-restricted T-cell responses against the CYP1B1(190-198) epitope thereby promoting tumor-specific cytotoxic immune responses Cytochrome P450 CYP1B1 190-198 exerts its biological activity primarily through antigen-specific activation of CD8 T cells In HLA-A2 transgenic mouse models this peptide delivered via plasmid DNA and poly(lactide-co-glycolide) microparticles demonstrates the ability to elicit CYP1B1 peptide-specific T-cell immunity Based on these pharmacological properties Cytochrome P450 CYP1B1 190-198 holds research potential in cancer immunotherapy and studies of tumor-specific cytotoxic T-cell responses
![eMolecules 344361-90-6 | ETHYL 4-METHYL-2-(METHYLTHIO)-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBOXYLATE | AstaTech | MFCD19442787 | 228.270 | C9H12N2O3S | 95.000 | CCOC(=O)c1c(C)nc(SC)[nH]c1=O | 1g | 384830780](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502178543.JPG-250.jpg)
eMolecules 344361-90-6 | ETHYL 4-METHYL-2-(METHYLTHIO)-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBOXYLATE | AstaTech | MFCD19442787 | 228.270 | C9H12N2O3S | 95.000 | CCOC(=O)c1c(C)nc(SC)[nH]c1=O | 1g | 384830780
ETHYL 4-METHYL-2-(METHYLTHIO)-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBOXYLATE | AstaTech | 344361-90-6 | MFCD19442787 | 228.270 | C9H12N2O3S | 95.000 | CCOC(=O)c1c(C)nc(SC)[nH]c1=O | 1g | 384830780
Medchemexpress LLC BAY-298 | 2471978-97-7 | 99.9% | 10 MM * 1 ML
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist. It demonstrates potent activity against human, rat, and cynomolgus monkey LH receptors, effectively reducing sex hormone levels. It is supplied as a 10 MM solution in DMSO.
- Orally active and selective LH-R antagonist
- Reduces sex hormone levels
- Potent inhibitory activity against human, rat, and cynomolgus monkey LH receptors
- Inhibits human ERG in HEK293 cells
- Lowers serum estradiol levels in proestrus female rats
Medchemexpress LLC Imidazo[1,2-a]pyrazine, 8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | 3023925-68-7 | C25H26N6O | 50 MG
YL-939 is a potent ferroptosis inhibitor that targets the PHB2/ferritin/iron axis. It efficiently protects cells from ferroptosis and has shown to ameliorate liver damage in an Acetaminophen (APAP)-induced acute liver injury model.
- Potent ferroptosis inhibitor
- Targets the PHB2/ferritin/iron axis
- Protects cells from ferroptosis
- Reduces ROS levels in cytosolic and membrane lipids
- Inhibits ferritinophagy by improving ferritin protein expression
- Ameliorates liver damage in APAP-induced acute liver injury models
- High purity of 99.03%
- Solid appearance, off-white to light yellow color
Medchemexpress LLC Phospho-Met c-Met antibody (YA175) | Protein A affinity purified | Predicted band size: 156 kDa; Observed band size: 170/140 kDa | 50 UL
MET is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor (HGF) ligand. It regulates various physiological processes, including proliferation, scattering, morphogenesis, and survival. This antibody is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Phospho-Met c-Met. It is supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol with 0.05% Sodium Azide as a preservative.
- Targets Phospho-Met c-Met
- Rabbit-derived monoclonal antibody
- Reacts with human samples
- Purified using protein A affinity
- Applicable in Western blot (WB) and immunohistochemistry-paraffin (IHC-P)
- For research use only
- Avoid repeated freeze / thaw cycles
Medchemexpress LLC TA-02 | 1784751-19-4 | 99.9% | 333.33 g/mol | C20H13F2N3 | 10 MG
This small-molecule research compound is a potent p38 MAPK inhibitor reported to have an IC50 of 20 nM and additional activity against TGFBR-2. It is supplied as a high-purity solid or DMSO solution for biochemical and cellular studies.
- Potent p38 MAPK inhibition (IC50 = 20 nM).
- Also inhibits TGFBR-2.
- High purity (99.9%).
- Available as small solid quantities (e.g., 10 mg) and as a DMSO solution.
- Suitable for biochemical and cellular assay applications.
eMolecules 58304-65-7 | AstaTech | 1-CHLORO-2-METHYLPROPYL PROPIONATE | 1g | 233619311 | 25803 | 95 | MFCD09033184 | 164.63 | C7H13ClO2
AstaTech | 1-CHLORO-2-METHYLPROPYL PROPIONATE | 1g | 233619311 | 25803 | 95.000 | 58304-65-7 | MFCD09033184 | 164.630 | C7H13ClO2
Medchemexpress LLC Met kinase-IN-2 | 2101241-90-9 | 98.4% | 562.59 g/mol | C33H27FN4O4 | 5 MG
MET kinase-IN-2 is a potent, selective MET (c-Met/HGFR) kinase inhibitor with an enzymatic IC50 of 7.4 nM. The compound shows cellular growth inhibition across multiple cancer cell lines and demonstrates oral antitumor efficacy in xenograft models. It is supplied for preclinical research and is well characterized for purity and molecular properties.
- Potent MET kinase inhibition (IC50 7.4 nM).
- Selective profile with additional activity against AXL, Flt4, KDR, Mer, TEK, and TYRO3.
- Orally bioavailable with demonstrated in vivo antitumor efficacy.
- Documented cellular activity in multiple cancer cell lines.
- High purity and characterized molecular weight and formula.
Medchemexpress LLC N-benzyl-N-butyl-4-(phenylsulfamoyl)benzamide | 2244678-29-1 | 98.4% | 50 MG
TH-257 (CAS 2244678-29-1) is a small-molecule allosteric inhibitor of LIM kinase 1 and 2 used as a biochemical research probe to study LIMK-mediated signaling pathways in vitro.
- Potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM.
- Molecular formula C24H26N2O3S and molecular weight 422.54 g/mol.
- High purity (98.36%) suitable for in vitro biochemical studies.
- Supplied as a solid powder and as a 10 mM solution in DMSO; common pack sizes include 5 mg, 10 mg, 50 mg, and 100 mg.
Selleck Chemical LLC (R)-Nepicastat HCl S4926-10mg
(R)-Nepicastat HCl (RS-25560-198) the R-enantiomer of Nepicastat HCl is a potent and selective inhibitor with IC50 of 25 1 nM and 18 3 nM for bovine and human dopamine- -hydroxylase with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors
Medchemexpress LLC YL-939 | 3023925-68-7 | 99.0% | 426.51 g/mol | C25H26N6O | 10 MG
YL-939 is a small-molecule ferroptosis inhibitor that prevents iron-dependent cell death by modulating the PHB2/ferritin/iron axis. It has been characterized as a non-classical ferroptosis inhibitor with demonstrated protective activity in cellular assays.
- Inhibits ferroptosis via the PHB2/ferritin/iron axis.
- Demonstrated cellular activity in vitro against ferroptotic insults.
- High chemical purity (~99.0%) and defined physical properties.
- Off-white to light-yellow solid, molecular weight 426.51 g/mol.
- CAS number 3023925-68-7 for unambiguous identification.
- Soluble in DMSO (100 mg/mL) and amenable to in vivo formulations.
- Store as powder at -20°C; limited stability in solution.
Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 10 MG
JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK variants, including those with resistance mutations, and shows selectivity against other kinases. This compound inhibits the growth of several cancer cell lines and exhibits good oral bioavailability, with the ability to penetrate the central nervous system in mice.
- Potent inhibitor of EML4-ALK variants, including G1202R resistance mutation
- Selective against various other kinases such as IRAK1, CLK4, and RET
- Inhibits the growth of cancer cell lines like H3122 and DFCI76
- Good oral bioavailability in mice
- Penetrates the central nervous system in mice