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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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Antitumor agent-127 (compound 1) is a parent macrocyclic peptide that displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines. It does not induce apoptosis in Mia PaCa-2 cells, a model pancreatic tumor cell line with low cell surface expression of ROR1.
Displays nanomolar cell-based binding to ROR1.
Demonstrates good internalization in 786-O and MDA-MB-231 tumor cell lines.
Does not induce apoptosis in Mia PaCa-2 cells.
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(S)-(-)-Propranolol hydrochloride is a chiral antihypertensive agent with approximately 100-fold higher potency than its R-enantiomer. It is used for studies on hypertension, angina pectoris, and arrhythmia. It is for research use only and not sold to patients.
Chiral antihypertensive agent
Approximately 100-fold higher potency than R-enantiomer
Used for studies on hypertension
Used for studies on angina pectoris
Used for studies on arrhythmia
For research use only
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This cccDNA inhibitor (Compound 1-B) exhibits anti-HBV activity. It has an IC50 of 0.14 μM for HBeAg and an IC50 of 0.08 μM for HBsAg in in vitro assays. It inhibits covalently closed circular DNA (cccDNA) and is applicable to research related to hepatitis B virus infection.
CccDNA inhibitor
Anti-HBV activity
Inhibits HBeAg production in HepDES19 cells with an IC50 of 0.14 μM
Inhibits HBsAg production in cryopreserved primary hepatocytes, with an IC50 of 0.08 μM
Applicable to research related to hepatitis B virus infection
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FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2). It induces robust erythropoietin and modest fetal hemoglobin in vivo.
Potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2)
IC50 of 3.9 μM against PHD2
Induces robust erythropoietin in vivo
Induces modest fetal hemoglobin in vivo
Stabilizes HIF-1α and HIF-2α in Hep3B cells
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. (beta)-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. (beta)-NF-JQ1 uses (beta)-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein interactions. (beta)-NF-JQ1 shows potent anticancer activity associated with protein knockdown activity. . purity: 99%
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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trans-2-Heptenal has a pungent grassy smell and is commonly used as a flavoring agent in the food and beverage industry In addition it can be used as an intermediate in the synthesis of various organic compounds including fragrances pharmaceuticals and agrochemicals Its unique chemical properties make it an important ingredient in a variety of industrial processes notably in the production of perfumes and air fresheners
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trans-BAY-850 is the trans isomer of BAY-850, a small-molecule inhibitor of ATPase family AAA domain-containing protein 2 (ATAD2). It is provided as a research reagent for biochemical and cell-based studies to probe ATAD2 function and chromatin interactions. The compound is a solid with molecular formula C38H44ClN5O3 and molecular weight 654.24 g/mol.
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FG-3246 (FOR46) is a humanized antibody expressed in CHO cells that targets CD46 FG-3246 (FOR46) has a huIgG1 heavy chain and a hu light chain with a predicted molecular weight (MW) of 143 6 kDa The isotype control for FG-3246 (FOR46) can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
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