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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
MW 369.3 Da, Purity >95%. Irreversible inhibitor of trypsin and trypsin-like serine proteases. Blocks LPS- or cytokine-induced NF-κB activation. Inhibits caspase processing; blocks apoptosis. Active in vitro and in vivo.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. It has potential value for tumor research. NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases, and abolishes human adipocytes in a dose-dependent and reversible manner lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects.
Selective human ATGL inhibitor
Targets enzymatically active patatin-like domain
Potential for tumor research
Selectively inactivates human and nonhuman primate ATGL
Abolishes human adipocytes in a dose-dependent and reversible manner lipolysis
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Recombinant full-length human CCT2 (chaperonin containing TCP1 subunit 2) expressed in E. coli with N-terminal 6xHis and SUMO tags. Supplied as purified protein for biochemical, structural, and interaction studies; store frozen and aliquot to preserve integrity.
Purified full-length human CCT2 protein.
N-terminal 6xHis and SUMO tags facilitate purification and detection.
Purity greater than 90% as determined by reducing SDS-PAGE.
Approximate molecular weight ~66 kDa for identification by SDS-PAGE.
Available in small microgram pack sizes suitable for assay development.
Stable when stored frozen; aliquot to minimize freeze-thaw cycles.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More