Aminobenzoic acids and derivatives
Selleck Chemical LLC SNS-314 Mesylate
SNS-314 Mesylate is a potent and selective inhibitor of Aurora A Aurora B and Aurora C with IC50 of 9 nM 31 nM and 3 nM respectively and less potent to Trk A/B Flt4 Fms Axl c-Raf and DDR2
Medchemexpress LLC 10(Z)-pentadecenoic acid | 84743-29-3 | 99.9% | 10 MG
10(Z)-Pentadecenoic acid is a 15-carbon monounsaturated fatty acid (cis-10 configuration) commonly used as a biochemical reagent and reference standard in lipid research and analytical chemistry.
- used as a reference standard in fatty acid analysis.
- high purity suitable for analytical and profiling applications.
- liquid oil form facilitates handling and sample preparation.
- available in small research quantities such as 10 mg.
- suitable for studies of fatty acid metabolism and lipid profiling.
Apexbio Technology LLC Arcyriaflavin A 118458-54-1 1mg
Arcyriaflavin A (CAS 118458-54-1) is a small-molecule inhibitor targeting the cyclin-dependent kinase 4 (CDK4)/cyclin D1 complex and CaMKII It is designed to inhibit these kinases thereby modulating cell cycle progression and related signaling pathways Arcyriaflavin A exerts its biological activity primarily through inhibition of CDK4/cyclin D1 and CaMKII In cell-based assays Arcyriaflavin A inhibits the CDK4/cyclin D1 kinase complex with an IC of approximately 59 nM and suppresses human cytomegalovirus (HCMV) replication with an IC of around 0 2 M Based on these pharmacological properties Arcyriaflavin A holds research potential in studies of cell cycle regulation antiviral mechanisms and kinase-inhibitor interactions
Medchemexpress LLC BETd-246 50mg | 2140289-17-2 | 946.02 | C48H55N11O10 | 50 MG
BETd-246 is a second-generation PROTAC-based BET bromodomain degrader that induces targeted degradation of BET family proteins (BRD2, BRD3, BRD4). It demonstrates high potency, selectivity, and antitumor activity in cellular assays and in vivo models. Supplied for research use only.
- Enables targeted degradation of BET proteins.
- High potency and selectivity in cellular assays.
- Induces dose-dependent depletion of BRD2, BRD3, and BRD4.
- Demonstrates antitumor efficacy in PDX models.
- Soluble in DMSO at high concentration for in vitro use.
- Stable when stored under recommended conditions.
Medchemexpress LLC 2,2'-methylenebis(4-methyl-6-tert-butylphenol) | 119-47-1 | 99.8% | 500 G
GERI-BP002-A is a small-molecule inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) isolated from Aspergillus fumigatus F93, provided for research use with reported cytotoxic activity against multiple cancer cell lines.
- High purity (99.8%) for reliable experimental results.
- Molecular formula C23H32O2 and molecular weight 340.50 g·mol⁻¹.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Storage stability in solvent: -80°C (2 years), -20°C (1 year).
- Available in multiple pack sizes up to 500 G for scale flexibility.
- Intended for research use only; not for human or clinical use.
Apexbio Technology LLC AC 45594 13037-86-0 50mg
AC 45594 (CAS 13037-86-0) is a synthetic inverse agonist of steroidogenic factor-1 (SF-1) a constitutively active nuclear receptor regulating adrenal/gonadal differentiation and steroid hormone biosynthesis By binding SF-1 it inhibits SF-1 mediated transcription and modulates steroidogenic gene expression In human adrenal cortical H295R cells AC 45594 suppresses SF-1 transcriptional activity with an IC of 50 100 nM reduces cyclic AMP induced StAR mRNA and protein expression and dose-dependently decreases proliferation while promoting apoptosis in SF-1 overexpressing cells These properties support its research use in studying SF-1 dependent regulation of steroidogenesis proliferation and survival in adrenal and endocrine models
