Benzenesulfonamides
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Apexbio Technology LLC RN 1734 946387-07-1 10mg
RN 1734 (CAS 946387-07-1) is a selective antagonist of the TRPV4 ion channel demonstrated to inhibit 4 PDD-induced TRPV4 activation It exhibits low micromolar IC50 values against human (2 3 M) rat (5 9 M) and mouse (3 2 M) TRPV4 indicating high potency across species In experimental models RN 1734 decreases the production of inflammatory cytokines TNF- and IL-1 without affecting the number of oligodendrocyte lineage markers Due to these properties RN 1734 is widely utilized in studies investigating TRPV4 function and the role of this channel in inflammation-related pathologies
