Choose the brand aligned with your industry so we can best serve your needs.
For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
Organic compounds that consist of a phenol ring with a ciclohexane substitution; includes compounds in which the ciclohexane group has additional substitutions.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
AZD8848 is a selective toll-like receptor 7 (TLR7) anteagent agonist developed for asthma and allergic rhinitis research. It shows good activity against TLR7, with cellular pEC50s of 7.0 for human TLR7 and 6.6 for rat TLR7. It has an EC50 of 4 nM in the induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for the inhibition of IL-5. AZD8848 has no activity against human TLR8 or any other human TLRs. In vivo, it has a good pharmacokinetics in Brown Norway rats and suppresses ovalbumin (OVA) challenge in a rat allergy model.
Appearance: solid
Color: white to off-white
Shipping: room temperature in continental US; may vary elsewhere
Storage:
Powder: -20°C for 3 years, 4°C for 2 years
In solvent: -80°C for 6 months, -20°C for 1 month
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an IC50 of 2 μM. It demonstrates over 16-fold selectivity for Tip60 compared to PCAF, p300, and GCN5. This compound is known to induce apoptosis in prostate cancer cells.
Activates caspase 3 and caspase 9 in a time- and concentration-dependent manner.
Decreases acetylated histone H4K16, H3K14, and H4K8 levels.
Reduces androgen receptor, prostate-specific antigen, p53, and p21 protein levels.
Induces apoptosis in LNCaP cells.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Medchemexpress, HY-10790 5mg Cilomilast CAS:153259-65-5 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More