Phenoxy compounds
Apexbio Technology LLC LRRK2-IN-1 1234480-84-2 10mg
LRRK2-IN-1 (CAS 1234480-84-2) is a selective small-molecule inhibitor of leucine-rich repeat kinase 2 (LRRK2) a cytoplasmic kinase implicated in Parkinson s disease and Crohn s disease pathogenesis LRRK2-IN-1 competitively inhibits ATP binding to LRRK2 demonstrating an in vitro IC50 of 13 nM against wild-type LRRK2 and 6 nM against the G2019S mutant In HEK293 cells expressing GFP-tagged wild-type or G2019S LRRK2 it shows dose-dependent inhibition with IC50 values of 0 17 M and 0 04 M respectively The compound displays selectivity towards LRRK2 over other kinases and does not affect LRRK1 LRRK2-IN-1 is utilized to investigate LRRK2 signaling pathways phosphorylation events and disease-related mutations in neurodegeneration and inflammation research
