Phenoxy compounds
Medchemexpress LLC HY-17009 5mg Medchemexpress, Iguratimod CAS:123663-49-0 Purity:>98%
Medchemexpress, HY-17009 5mg Iguratimod CAS:123663-49-0 Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2 , with an IC 50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor ( MIF ) with an IC 50 of 6.81 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC GSK2945 hydrochloride | 98.5% | 457.80 | 100 MG
GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
- Dose-dependently enhances the transcriptional activity of Rev-erbα and a Bmal1 (a target gene of REV-ERBs) luciferase reporter (EC50 of 2.05 μM).
- Treatment (20 μM; 12 hours and 24 hours; mouse and human primary hepatocytes) increases levels of Cyp7a1/CYP7A1 in mouse and human primary hepatocytes.
- Treatment (20 μM) also increases Lrh-1/LRH-1 (a known hepatic activator of Cyp7a1/CYP7A1) mRNA and protein.
- Treatment (0-10 mg/kg; intraperitoneal injection; twice every day; for 7 days; male C57BL/6 mice) increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice.