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Organic compounds that consist of a phenyl group with a carboxylic acid group substitution; a carboxylic acid contains a carbon atom bonded to both a carbonyl group and a hydroxyl group.
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Diclofenac is a potent and nonselective anti-inflammatory agent that acts as a COX inhibitor. It induces apoptosis of neural stem cells (NSCs) by activating the caspase cascade.
Potent and nonselective anti-inflammatory properties
Inhibits COX enzymes
Induces apoptosis in neural stem cells
Activates caspase cascade
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Ompenaclid (RGX-202) is an oral small-molecule inhibitor of the creatine transporter SLC6A8 used as a research compound and reference standard in preclinical studies. It inhibits creatine import, reduces intracellular phosphocreatine and ATP, and has demonstrated tumor apoptosis induction in model systems.
Inhibits SLC6A8 creatine transporter in vitro and in vivo.
Reduces intracellular phosphocreatine and ATP levels.
Induces tumor cell apoptosis in preclinical studies.
Available as high-purity solid or solution for research use.
Characterized by confirmed molecular formula and molecular weight.
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Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent that acts as a COX inhibitor. It demonstrates IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. This compound also induces apoptosis of neural stem cells (NSCs) by activating the caspase cascade.
Potent and nonselective anti-inflammatory activity.
Effective COX inhibitor in both human and ovine cells.
Induces apoptosis in neural stem cells through caspase cascade activation.
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Diclofenac (CAS 15307-86-5) is a phenylacetic acid derivative classified as a non-steroidal anti-inflammatory drug (NSAID) It exerts its biological activity by inhibiting cyclooxygenase (COX)-1 and COX-2 enzymes thereby suppressing prostaglandin synthesis that mediates inflammation and pain signaling Structurally the incorporation of two ortho chlorine atoms on the phenyl ring increases molecular rigidity which has been associated with enhanced potency Diclofenac is widely used in research to study inflammatory pathways pain mechanisms and as a reference compound in the evaluation of cyclooxygenase inhibition and potential gastrointestinal protective strategies in combination therapies
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