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Organic compounds that consist of a phenyl group with a carboxylic acid group substitution; a carboxylic acid contains a carbon atom bonded to both a carbonyl group and a hydroxyl group.
Diclofenac (CAS 15307-86-5) is a phenylacetic acid derivative classified as a non-steroidal anti-inflammatory drug (NSAID) It exerts its biological activity by inhibiting cyclooxygenase (COX)-1 and COX-2 enzymes thereby suppressing prostaglandin synthesis that mediates inflammation and pain signaling Structurally the incorporation of two ortho chlorine atoms on the phenyl ring increases molecular rigidity which has been associated with enhanced potency Diclofenac is widely used in research to study inflammatory pathways pain mechanisms and as a reference compound in the evaluation of cyclooxygenase inhibition and potential gastrointestinal protective strategies in combination therapies
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