Phenylhydrazines
Medchemexpress LLC Bendamustine (hydrochloride) | 3543-75-7 | 99.89% | C16H22Cl3N3O2 | 100 MG
Bendamustine hydrochloride is a purine analogue and a DNA cross-linking agent that activates DNA-damage stress response and apoptosis. It possesses potent alkylating, anticancer, and antimetabolite properties.
- A purine analogue.
- Acts as a DNA cross-linking agent.
- Activates DNA-damage stress response.
- Induces apoptosis.
- Exhibits potent alkylating properties.
- Demonstrates anticancer effects.
- Possesses antimetabolite characteristics.
- Induces p21 (Cip1/Waf1) and NOXA genes.
- Increases the expression of p53 in SU-DHL-1 cells.
- Blocks mitotic checkpoints and causes mitotic catastrophe.
- Reduces the viability of multiple myeloma cell lines.
- Induces specific caspase-dependent multiple myeloma cell death.
- Inhibits the spindle-assembly checkpoint.
Medchemexpress LLC Almonertinib (hydrochloride) | 2134096-03-8 | 98.9% | 562.11 | 50 MG
Almonertinib hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It exhibits high selectivity for EGFR-sensitizing and T790M resistance mutations and is utilized in non-small cell lung cancer research. It can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Potent inhibitory activity against T790M (IC50: 0.37 nM), T790M/L858R (IC50: 0.29 nM), and T790M/Del19 (IC50: 0.21 nM)
- Less effective against wild-type EGFR (IC50: 3.39 nM)
- Used for research in non-small cell lung cancer (NSCLC)
- Inhibits other EGFR sensitive mutations such as G719X, del19, L858R, and L861Q
Medchemexpress LLC Valacyclovir hydrochloride | 124832-27-5 | 99.9% | 360.80 | 100 MG
Valacyclovir hydrochloride is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. It inhibits HSV-1 W (50=2.9 μg/ml) and is a proagent of Aciclovir.
- IC50 and target: HSV-1, 2.9 μg/mL (IC50).
- In vitro: Uptake is concentration dependent and saturable, with hPEPT1 dominating intestinal transport.
- In vivo: Effective for treating genital herpes (1 g twice daily) and recurrences. A 1 g daily dose is as effective as 2 g daily and can be administered once a day. Studies in immunosuppressed mice showed reduced erythema, eliminated ear paralysis, ear lesions, and death.
Medchemexpress LLC Ampreloxetine hydrochloride | 1227056-87-2 | 99.5% | 357.80 | C18H19ClF3NO | 10 MG
Ampreloxetine hydrochloride is the hydrochloride salt of ampreloxetine (TD-9855), an orally active, CNS-penetrant inhibitor of norepinephrine and serotonin reuptake. Supplied as a research-grade small-molecule reagent, it is intended for preclinical pharmacology and transporter studies investigating NET and SERT function.
- High reported purity (99.5%) suitable for research assays.
- Provided as a solid for accurate weighing and formulation.
- Suitable for in vitro and in vivo preclinical studies of monoamine transporters.
- Well-characterized molecular properties (C18H19ClF3NO, MW 357.80).
- Available in small milligram package sizes for dose-ranging and screening.