Phenylhydrazines
Medchemexpress LLC Triprolidine hydrochloride monohydrate | 6138-79-0 | 99.9% | 5 MG
Triprolidine hydrochloride monohydrate is a first-generation antihistamine that acts as an oral active histamine H1 antagonist. It is utilized in the research of allergic rhinitis and has been observed to induce spinal motor and sensory block in rats.
- First-generation antihistamine
- Oral active histamine H1 antagonist
- Used for research of allergic rhinitis
- Exhibits spinal motor and sensory block in rats
Medchemexpress LLC Pheniprazine hydrochloride | 66-05-7 | 98.7% | 186.68 g·mol⁻¹ | C9H15ClN2 | 50 MG
Pheniprazine hydrochloride is the hydrochloride salt of pheniprazine, an irreversible, nonselective monoamine oxidase (MAOI) inhibitor supplied for research use in biochemical and pharmacological studies of monoamine systems and depression.
- Irreversible, nonselective monoamine oxidase inhibitor.
- Useful research tool for studies of depression and monoaminergic signaling.
- Supplied as a white to off-white solid.
- Typical purity about 98.7%.
- Available in small research quantities, for example 50 mg.
- Store solid at 4°C, sealed and away from moisture; in solution store at -80°C for long-term storage.
Medchemexpress LLC Tetracycline hydrochloride | 64-75-5 | 98.3% | 1 ML
Tetracycline hydrochloride is a broad-spectrum antibiotic with oral activity. It exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas, and rickettsiae. This compound is suitable for research on infections and its activity extends to inhibiting L-amyloid aggregate formation.
- Active against gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, and rickettsiae
- Useful for research on infections
- Inhibits L-amyloid aggregate formation and disassembles pre-formed fibrils
- Can be utilized in animal modeling for genetically engineered disease models
- Capable of inducing tumor regression based on BCR-ABL gene silencing
Medchemexpress LLC -PD 128907 hydroc 10mM | 300576-59-4 | 98.92% | 285.77 | 50 MG
(+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist. It demonstrates high selectivity for human and rat D3 receptors, with Ki values of 1.7 nM and 0.84 nM respectively, showing over 100-fold and 900-fold selectivity compared to human and rat D2 receptors. This compound is intended for research use only.
- Selective dopamine D2/D3 receptor agonist.
- Exhibits high affinity for D3 receptors in both human and rat models.
- Shows significant selectivity over D2 receptors.
- Decreases dialysate dopamine levels in wild-type mice, being more potent than in D3 knock-out mice.
Medchemexpress LLC (+)-PD 128907 hydrochloride | 300576-59-4 | 98.92% | 285.77 | 50 MG
(+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist, with Kis of 1.7 nM and 0.84 nM for human and rat D3 receptors, and 179 nM and 770 nM for human and rat D2 receptors, respectively. This product is for research use only and is not sold to patients.
- Selective dopamine D2/D3 receptor agonist.
- Kis of 1.7 nM (human D3) and 0.84 nM (rat D3).
- Selectivity over human and rat dopamine D2 receptor (>100-fold and 900-fold, respectively).
- Decreases dialysate DA levels in D3 knock out mice and wild-type mice, with higher potency in wild-type.
Medchemexpress LLC Lomefloxacin hydrochloride | 98079-52-8 | 99.97% | 5 G
Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. It prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. This compound induces ROS production and apoptosis, demonstrating broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria, and also exhibits anticancer effects against melanoma.
- Orally active difluoroquinolone antibiotic
- Inhibits bacterial topoisomerase II
- Induces ROS production and apoptosis
- Broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria
- Exhibits anticancer effects against melanoma
- Useful in studying systemic bacterial infections
- Reduces viable cell counts of common bacteria
- Decreases viability and induces ROS production in melanoma cells
Apexbio Technology LLC CK-636 442632-72-6 10mM (in 1mL DMSO)
CK-636 is a small molecule inhibitor targeting the Arp2/3 protein complex which regulates actin nucleation and polymerization Specifically CK-636 binds between Arp2 and Arp3 subunits preventing them from adopting the active conformation needed for initiating filamentous actin assembly In biochemical assays CK-636 inhibited Arp2/3-mediated actin polymerization induced by human bovine and fission yeast Arp2/3 complexes with reported IC50 values of 4 M 32 M and 24 M respectively Additionally CK-636 suppressed Arp2/3-dependent actin filament formation in live SKOV3 cells infected with Listeria bacteria exhibiting a concentration-dependent effect (IC50 approximately 22 M) This compound serves as a research tool for studying molecular mechanisms and biological functions involving Arp2/3-mediated cytoskeletal remodeling particularly in the context of cell adhesion junctional integrity and epithelial differentiation