Phthalic acid and derivatives
eMolecules 18699-48-4 | ChemScene | Diisobutyl terephthalate | 250mg | 632324596 | CS-0160333 | MFCD01682719 | 278.348 | C16H22O4
ChemScene | 1-(4-Fluorophenyl)butane-13-dione | 100mg | 536795038 | CS-0060858 | 29681-98-9 | MFCD00463139 | 180.178 | C10H9FO2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Apexbio Technology LLC Cyclic Pifithrin-α hydrobromide 511296-88-1 25mg
Cyclic Pifithrin- hydrobromide (CAS 511296-88-1) is a synthetic small molecule that functions as an inhibitor of the tumor suppressor protein p53 By blocking p53-dependent transcriptional activation of response genes it interferes with p53-mediated cellular processes such as apoptosis and cell cycle arrest In vitro Cyclic Pifithrin- hydrobromide inhibits p53-dependent apoptosis and DNA damage-induced growth arrest in various cell models without notable effects on p53-deficient cells In vivo it protects mice from the toxic side effects of genotoxic cancer therapies likely through suppression of p53-dependent pathways This compound is utilized in research investigating p53 biology cellular stress responses and modulation of chemotherapeutic toxicity
![Medchemexpress LLC Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-(hydrogen phosphate), sodium salt | 93882-12-3 | 99.9% | 493.79 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438753-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-(hydrogen phosphate), sodium salt | 93882-12-3 | 99.9% | 493.79 | 1 ML
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). It is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM, and inhibits PDE III and PDE IV with IC50Epac. 8-CPT-Cyclic AMP sodium is also a potent Epac activator. It has been shown to delay TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils at a concentration of 0.7 mM, being more efficient against apoptosis induced by TNF-α/CHX.
- Selective activator of cyclic AMP-dependent protein kinase (PKA).
- Potent inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA).
- Inhibits PDE III and PDE IV.
- Potent Epac activator.
- Can delay TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils.
Apexbio Technology LLC Methotrexate disodium 7413-34-5 200mg
Methotrexate disodium (CAS 7413-34-5) is a small-molecule inhibitor targeting dihydrofolate reductase (DHFR) It is designed to inhibit DHFR activity thereby disrupting the enzymatic reduction of dihydrofolate to tetrahydrofolate and impairing DNA and RNA biosynthesis Methotrexate disodium exerts its biological activity primarily through DHFR inhibition In in vitro studies methotrexate disodium demonstrates inhibitory activity with an IC50 value in the nanomolar range (approximately 5 to 50 nM depending on assay conditions and cell models) Based on these pharmacological properties methotrexate disodium holds research potential in autoimmune disorders such as rheumatoid arthritis and psoriasis as well as in antineoplastic studies involving acute lymphoblastic leukemia
Apexbio Technology LLC Cyclic Pifithrin-α hydrobromide 511296-88-1 50mg
Cyclic Pifithrin- hydrobromide (CAS 511296-88-1) is a synthetic small molecule that functions as an inhibitor of the tumor suppressor protein p53 By blocking p53-dependent transcriptional activation of response genes it interferes with p53-mediated cellular processes such as apoptosis and cell cycle arrest In vitro Cyclic Pifithrin- hydrobromide inhibits p53-dependent apoptosis and DNA damage-induced growth arrest in various cell models without notable effects on p53-deficient cells In vivo it protects mice from the toxic side effects of genotoxic cancer therapies likely through suppression of p53-dependent pathways This compound is utilized in research investigating p53 biology cellular stress responses and modulation of chemotherapeutic toxicity
Medchemexpress LLC 8-CPT-Cyclic AMP sodium | 93882-12-3 | 99.7% | 493.79 | 25 MG
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). It is also identified as a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. Additionally, 8-CPT-Cyclic AMP sodium inhibits PDE III and PDE IV with IC50Epac and functions as a potent Epac activator.
- Selective activator of cyclic AMP-dependent protein kinase (PKA).
- Potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM.
- Inhibits PDE III and PDE IV.
- Potent Epac activator.
- Delays TNF-/CHX-induced and α-Fas-induced apoptosis in neutrophils.
Medchemexpress LLC Cyclic GMP (TBAOH) | 99.07% | 604.68 | 25 MG
Cyclic GMP (TBAOH) | 99.07% | 604.68 | 25 MG
Medchemexpress LLC 8-CPT-Cyclic AMP sodium | 93882-12-3 | 99.7% | 493.79 | 50 MG
8-CPT-Cyclic AMP sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA) and a potent Epac activator. It also acts as an inhibitor for specific phosphodiesterases.
- Selective activator of cyclic AMP-dependent protein kinase (PKA).
- Potent inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM.
- Inhibits PDE III and PDE IV.
- Potent Epac activator.
Medchemexpress LLC Cyclic GMP | 7665-99-8 | 99.8% | 345.21 | 10 MG
Cyclic GMP | 7665-99-8 | 99.8% | 345.21 | 10 MG
Selleck Chemical LLC Terephthalic acid
Terephthalic acid (para-Phthalic acid 1 4-Benzenedioic acid) a raw material for polyethylene terephthalate (PET) production is one of the most important chemicals in petrochemical industry Terephthalic acid can be used to induce animal models of Bladder Urolithiasis
Medchemexpress LLC Terephthalic acid | 100-21-0 | 99.99% | 166.13 | 50 G
Terephthalic acid is an isomer and a precursor of polyester PET, used in clothing and plastics. It can also be utilized to build skin tumor models and promote excessive cell proliferation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway. In vivo, it can lead to bladder stone formation in animal models, particularly in weanling mice at higher doses.
- Isomer and precursor of polyester PET
- Used to build skin tumor models
- Promotes excessive cell proliferation
- Induces skin tumor formation
- Metabolized to form calcium terephthalate, potentially leading to bladder stone formation
Medchemexpress LLC Terephthalic acid | 100-21-0 | 99.99% | 166.13 | 25 MG
Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. It can also be used to build skin tumor models.
- Isomer and precursor of polyester PET.
- Can be used to build skin tumor models.
- Can promote excessive cell proliferation and induce skin tumor formation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway.
- In animal modeling, it can create skin tumor models.
- Metabolized in the body to form calcium terephthalate or calcium hydrogen terephthalate, leading to oversaturation in the urine and promoting the formation of bladder stones.
Medchemexpress LLC Cyclic somatostatin | 38916-34-6 | 99.9% | 1637.88 | 50 MG
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor primarily used in research for severe, acute hemorrhages of gastroduodenal ulcers. This neuropeptide, co-stored with acetylcholine in cardiac parasympathetic innervation, directly influences the contraction of ventricular cardiomyocytes and inhibits the contractile response of isoprenaline with an IC50 value of 13 nM.
- Potent growth hormone-release inhibiting factor
- Investigated for its role in severe, acute hemorrhages of gastroduodenal ulcers
- Neuropeptide co-stored with acetylcholine in cardiac parasympathetic innervation
- Directly affects the contraction of ventricular cardiomyocytes
- Exhibits strong inhibitory effect on the contractile response of isoprenaline (IC50 value of 13 nM)
- Valuable tool for cardiovascular disease research