Immunoproteasome inhibitor 1 is a potent, reversible, and time-independent inhibitor of both immunoproteasome and proteasome. It exhibits Ki values of 1.18 μM in β5c, 0.27 μM in β1i, and 1.91 μM in β5i subunits. The compound demonstrates high binding affinity for the β1i subunit and good inhibitory properties towards the β5i and β5c subunits. This inhibitor can be utilized for research into certain neoplastic diseases.
- Potent, reversible, and time-independent inhibition
- Targets both immunoproteasome and proteasome subunits (β5c, β1i, β5i)
- High binding affinity for β1i subunit (0.27 μM)
- Useful for research into neoplastic diseases