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Styrenes

Organic compounds that consist of a benzene ring with a vinyl functional group in the following chemical formula: C₆H₅CH=CH₂; can also be called vinyl benzene.

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1

Medchemexpress LLC Methanone, 8-oxa-2-azaspiro [4.5]dec-2-yl[2-[(2-pyrazinylmethyl)amino]-5-pyrimidinyl]- | 2173134-00-2 | 99.9% | 10 MM * 1 ML
SDP

PFI-653 is a chemical probe and a potent vanin-1 inhibitor, also known as Vanin-1-IN-1. It targets cell surface-associated inositol (GPi)-anchored protein vanin-1, which is involved in metabolism and inflammation. This compound effectively binds to and inhibits plasma vanin-1 across various species, including human, mouse, rat, and dog.

  • Chemical probe and vanin-1 inhibitor
  • Binds to plasma vanin-1 from multiple species
  • Exhibits low clearance rate and high bioavailability in vivo
  • Relevant for research in metabolism and inflammation

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2

Medchemexpress LLC 2-((5-bromo-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide | 2488892-01-7 | 99.4% | 487.35 g/mol | C17H20BrFN6O3S | 10 MG
SDP

TMX-2039 is a research-grade pan-cyclin-dependent kinase (pan-CDK) inhibitor intended for biochemical and cellular studies of cell cycle and transcriptional CDKs. Supplied as an off-white to light yellow solid with high reported purity, it is suitable for assay development, mechanism-of-action experiments, and probe validation in research settings.

  • Pan-CDK activity covering cell cycle and transcriptional CDKs.
  • High purity (≈99.4%) suitable for research applications.
  • Supplied as a solid powder for flexible formulation and dosing.
  • Available in small research-friendly pack sizes, e.g. 10 mg.
  • Stable under recommended storage: 4°C under nitrogen; in solvent, -80°C for 6 months or -20°C for 1 month.
  • Provides consistent material for biochemical and cellular assays.

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3

Sigma Aldrich 2,4-Dimethylstyrene

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

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4

TARGETMOL CHEMICALS INC AB-680 5MG
SDP

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AB-680 is a highly potent reversible and selective inhibitor of CD73 (an ectonucleotidase Ki 4.9 pM for hCD73) with anti-tumor activity displays >10000-fold selectivity over related ectonucleotidases CD39. purity: 97%

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5

TARGETMOL CHEMICALS INC AMODIAQUINE 10MG
SDP

Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Amodiaquine is a synthetic aminoquinoline used to treat malaria. purity: 98%

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6

TARGETMOL CHEMICALS INC TRANS-ACPD 10MG
SDP

Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S 3R)- and (1R 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50 2/15/23/800 uM mGluR2/1/5/4). purity: 99%

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7

Medchemexpress LLC CFTR(inh)-172 | 307510-92-5 | 99.8% | 409.40 | 1 MG
SDP

CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel. It reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM. The inhibition is complete in approximately 10 minutes (t1/2=4 minutes) and is reversed after washout with a t1/2 of approximately 5 minutes. It is nontoxic to FRT cells after 24 hours at concentrations up to 100 μM. It reduces open probability by > 90% and significantly reduces cholera toxin-induced fluid secretion in mouse models.

  • Potent and selective blocker of the CFTR chloride channel.
  • Reversibly inhibits CFTR short-circuit current.
  • Nontoxic to FRT cells at concentrations up to 100 μM.
  • Reduces open probability of CFTR by > 90%.
  • Reduces cholera toxin-induced fluid secretion in mouse models.

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8

Medchemexpress LLC Nms-873 | 1418013-75-8 | MFCD28009371 | >98% | 520.67 | C27H28N4O3S2 | 10 MG
SDP

NMS-873 is a potent, selective allosteric inhibitor of the VCP/p97 ATPase used in research to study protein homeostasis, ubiquitin-proteasome system dysfunction, and cell-cycle/DNA damage pathways. It exhibits strong biochemical inhibition (IC50 30 nM) and antiproliferative activity in cell lines at sub-micromolar concentrations.

  • Potent allosteric inhibition of VCP/p97 (IC50 30 nM).
  • Demonstrates antiproliferative activity in tumor cell lines (cellular IC50 ~0.08-2 μM).
  • Suitable for cell-based assays and biochemical studies of protein degradation and autophagy.
  • Provided as a solid with recommended storage conditions for powder and solutions.
  • Available in small-scale quantities (for example, 1 mg, 5 mg, 10 mg) for laboratory experiments.

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