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Organic compounds that consist of benzoic acid with a sulfanyl group substitution; a sulfanyl group is a sulfur atom bonded to a hydrogen atom via a single bond. Includes compounds that are directly derived from sulfanylbenzoic acid.
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OP-1074 is a pure anti-estrogen drug, functioning as a selective ER degrader (PA-SERD). It exhibits specific anti-estrogenic activity against ERα and ERβ.
Inhibits 17β-estradiol (E2)-stimulated transcription with IC50 values of 1.6 nM for ERα and 3.2 nM for ERβ.
Inhibits the proliferation of MCF-7 and CAMA-1 cells with IC50 values of 6.3 nM and 9.2 nM, respectively, after 24 hours.
Destabilizes ERα protein expression in MCF-7 and CAMA-1 cells at 100 nM for 24 hours.
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