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Organosulfur compounds that consist of a benzoic acid in which the hydroxyl group is exchanged for a thiol group (-SH). Includes compounds that are directly derived from thiobenzoic acid.
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Benfotiamine (22457-89-2) is a synthetic lipid-soluble derivative of thiamine (vitamin B1) It is designed to improve bioavailability and intervene in multiple biochemical pathways associated with hyperglycemia-induced damage such as the hexosamine biosynthetic pathway advanced glycation end-product (AGE) formation and diacylglycerol (DAG)-protein kinase C (PKC) signaling Benfotiamine exerts its biological activity primarily through modulation of these pathways It has been utilized in laboratory studies evaluating therapeutics to reduce diabetic neuropathy retinopathy and other complications arising from hyperglycemia Based on these pharmacological properties Benfotiamine holds research potential in the management of diabetic neuropathy retinopathy and associated hyperglycemic conditions
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