Benzenetriols and derivatives
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![Medchemexpress LLC Benzoic acid, 4-[4-[(2-bromoacetyl)amino]butyl]- | 10161-87-2 | 98.7% | 314.18 | 10 MM * 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Benzoic acid, 4-[4-[(2-bromoacetyl)amino]butyl]- | 10161-87-2 | 98.7% | 314.18 | 10 MM * 1 ML
KRA-533 is a potent KRAS agonist that functions by binding to the GTP/GDP binding pocket in the KRAS protein, which prevents GTP cleavage. This action leads to the accumulation of constitutively active GTP-bound KRAS, subsequently triggering both apoptotic and autophagic cell death pathways in cancer cells.
- Potent KRAS agonist
- Binds to GTP/GDP binding pocket in KRAS protein
- Prevents GTP cleavage
- Triggers apoptotic and autophagic cell death pathways in cancer cells
- Enhances KRAS activity
- Suppresses tumor growth in lung cancer mutant KRAS xenografts
- Induces apoptosis and autophagy in tumor tissues
- Directly binds to WT, G12C, G12D, and G13D mutant KRAS proteins
