Cresols
Chem-Impex International, Inc. 2-Bromo-4-methylphenol | MFCD00002151 | 100G
2-Bromo-4-methylphenol, MFCD00002151, 100G
Apexbio Technology LLC P 22077 1247819-59-5 10mM (in 1mL DMSO)
P 22077 (CAS 1247819-59-5) is a small molecule inhibitor targeting ubiquitin-specific protease 7 (USP7 also known as HAUSP) and to a lesser extent deubiquitinase USP4 USP7 modulates the stability of several regulatory proteins including p53 impacting apoptosis pathways in cancer biology P 22077 demonstrates potent USP7 inhibition with IC values of 8 6 nM in singleplex and 7 8 nM in multiplex in vitro assays and shows minimal activity against related enzymes DEN1 and SENP2core Cellular studies suggest that P 22077-mediated USP7 inhibition destabilizes Tip60 attenuating p53-dependent apoptosis The compound is currently utilized in preclinical research investigating the role of deubiquitination in tumorigenesis
Apexbio Technology LLC EZ Cap Mouse CD137 mRNA (m1Ψ HA tag) 1mg (1mg/mL)
Mouse CD137 mRNA encodes CD137P(4-1BB) mainly expressed on activated T cells natural killer (NK) cells and dendritic cells The ligand for CD137 is 4-1BBL primarily expressed on antigen-presenting cells Activation of CD137 enhances T-cell proliferation and survival and promotes the secretion of cytokines such as IFN- and IL-2 thereby strengthening immune responses Activating CD137 can enhance anti-tumor immune responses CD137 signaling pathways play complex roles in autoimmune diseases and transplant rejection EZ Cap Mouse CD137 mRNA (m1 HA tag) supplied at 1 mg/mL encodes mouse-derived CD137 cytokine fused to HA tag facilitating subsequent protein expression detection It contains a cap 1 structure generated through co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
eMolecules (S)-2-(3,5-DIMETHYLPHENYL)PYRROLIDINE | 1213334-10-1 | MFCD07772459 | 0.25g
AstaTech | (S)-2-(3,5-DIMETHYLPHENYL)PYRROLIDINE | 0.25g | 348150562 | F16975 | 95.000 | 1213334-10-1 | MFCD07772459 | 175.275 | C12H17N
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eMolecules Building Block Tool
Medchemexpress LLC NPR2 Human P. past 10ug
NPR2 Protein Human (P pastoris His) serves as the receptor for C-type natriuretic peptide NPPC/CNP activating guanylate cyclase upon ligand binding NPR2 potentially regulates skeletal growth indicating involvement in bone development Its interaction with C-type natriuretic peptide highlights its significance in mediating cellular responses especially in signaling pathways influencing skeletal growth dynamics NPR2 Protein Human (P pastoris His) is the recombinant human-derived Atrial natriuretic peptide receptor 2/NPR2 expressed by P pastoris with N-His labeled tag
BIOHIPPO h/m KRT10-sh-RFP-Puro
h/m KRT10-sh-RFP-Puro shRNA lentiviral vector expressing RFP with Puromycin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated h/m keratin 10 (KRT10) shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse keratin 10 (KRT10) The shRNA has been validated to meet or exceed 70% KRT10 knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs
BIOHIPPO h/m MCL1-sh-GFP-Puro
h/m MCL1-sh-GFP-Puro shRNA lentiviral vector expressing GFP with Puromycin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated human/mouse MCL1 shRNA lentivirus High-titer shRNA lentiviral particles specific for human/mouse MCL1 apoptosis regulator BCL2 family member (MCL1) The shRNA has been validated to meet or exceed 70% MCL1 knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs