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Filtered Search Results
Medchemexpress LLC Lerociclib (dihydrochloride) | 2097938-59-3 | 98.5% | 547.52 | 50 MG
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Lerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
- Induces a strong and sustained G1 arrest in CDK4/6 dependent cells.
- Inhibits RB phosphorylation within 1 hour post-treatment.
- Effectively inhibits proliferation in various tumor cell lines including breast, melanoma, leukemia, and lymphoma.
- Shows tumor regression in HER2+ breast cancer models.
- Demonstrates tumor growth inhibition in NSCLC tumor models.
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Apexbio Technology LLC Benserazide HCl 14919-77-8 5g
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Benserazide HCl is a small-molecule inhibitor targeting aromatic L-amino acid decarboxylase (AADC) It is designed to inhibit peripheral AADC activity thereby reducing dopamine synthesis outside the central nervous system and facilitating increased availability of administered levodopa to the brain Benserazide HCl exerts its biological activity primarily through selective inhibition of peripheral AADC In experimental research it is frequently combined with levodopa to investigate dopamine metabolism and neural transmission pathways Based on these pharmacological properties Benserazide HCl holds research potential in studies involving neurodegenerative disease models particularly Parkinson s disease to explore dopaminergic system dynamics and therapeutic mechanisms
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000663834 SURVODUTIDE SODIUM 1MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000380238 SP-96 10MM 1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000379293 TOFOGLIFLOZIN HYDRA 100MG
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Medchemexpress LLC OS-3-106 50mg | 1580000-17-4 | 450.60 g/mol | C25H30N4O2S | 50 MG
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A selective dopamine D3 receptor (D3R) agonist used as a research reagent in neuropharmacology and addiction studies. The compound is blood-brain barrier penetrant and binds D3R with high affinity (Ki = 0.2 nM). It is supplied as a solid with high purity and requires cold storage for extended stability.
- Selective D3 receptor agonist with Ki = 0.2 nM.
- Blood-brain barrier penetrant.
- Supplied as an off-white to light yellow solid.
- High purity suitable for research applications.
- Stable under recommended cold storage conditions.
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Medchemexpress LLC Dorzolamide hydrochloride | 130693-82-2 | 99.86% | C10H17ClN2O4S3 | 100 MG
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Dorzolamide hydrochloride | 130693-82-2 | 99.86% | C10H17ClN2O4S3 | 100 MG
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eMolecules 2 4 6-TRICHLOROPYRIMIDINE- 25G
5000216106 2 4 6-TRICHLOROPYRIMIDINE- 25G
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eMolecules TRIPENTAFLUOROPHENYLBOR 100G
5000216160 TRIPENTAFLUOROPHENYLBOR 100G
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Medchemexpress LLC Sulfaclozine sodium (sulfachloropyrazine sodium) | 23307-72-4 | 99.02% | 306.70 | 1 ML
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Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. It is commonly used for the treatment of various poultry diseases, particularly collibacteriosis, fowl cholera, and coccidiosis.
- Efficacious sulphonamide derivative
- Antibacterial and anticoccidial effects
- Used for treatment of various poultry diseases (collibacteriosis, fowl cholera, coccidiosis)
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000665714 POLYTETRAFLUOROETHY 25G
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eMolecules CHLORO4-METHOXYPHENYLM 100G
5000165865 CHLORO4-METHOXYPHENYLM 100G
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Medchemexpress LLC Coumaran (2,3-Dihydrobenzofuran) | 496-16-2 | 99.5% | C8H8O | 100 G
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Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor that exhibits antileishmanial activity. It may develop antiparasitic abilities by activating macrophages and demonstrating immunomodulatory effects. Coumaran can also serve as a biopesticide.
- AChE inhibitor
- Antileishmanial activity
- May acquire antiparasitic capabilities through activation of macrophages
- Exerts immunomodulatory activity
- Can be used as a biopesticide
- Active against promastigote (IC50=1.042 μM) and amastigote (IC50=1.43 μM) forms
- Not significantly cytotoxic to macrophages or erythrocytes at concentrations of 0.5-13 μM over 48 hours
- Increases phagocyte and lysosomal activity and nitrite (NO2-) levels at concentrations of 0.5-13 μM over 24 hours
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Medchemexpress LLC 3-Hydroxybenzaldehyde | 100-83-4 | 99.9% | C7H6O2 | 10 G
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3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for various phenolic compounds. It functions as a substrate for aldehyde dehydrogenase (ALDH) in both rats and humans, and is produced by 3-hydroxybenzyl-alcohol dehydrogenase. This compound has demonstrated vasculoprotective effects both in vitro and in vivo, positioning it as a promising subject for atherosclerosis research.
- Inhibits vascular smooth muscle cells proliferation, cell cycle, and cell migration
- Inhibits production levels of p-NF-κB and p-p38 increased by TNF-α in human umbilical vein endothelial cells
- Exhibits anti-thrombic effects in vivo
- Considered for research on atherosclerosis
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Medchemexpress LLC AS 1411 sodium (AGRO-100 sodium) | 99.5% | 8272.31 | 1 MG
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AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer that targets nucleoproteins. It inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and serves as a carrier to precisely deliver nanoparticles, oligonucleotides, and small molecules to cancer cells. It reduces PRMT5 expression, inhibiting tumor growth in DU145 prostate cancer cells, and blocks the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells.
- Inhibits tumor cell proliferation.
- Reduces PRMT5 expression.
- Blocks nucleoprotein binding to bcl-2 mRNA.
- Inhibits breast cancer cell proliferation when coupled with Jin nanospheres.
- Crosses the blood-brain barrier with low tissue toxicity.
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